The functional and anatomical characterization of three spinal output pathways of the anterolateral tract.

Autor:	Chen H; Tsinghua Medicine, Tsinghua University, Beijing 100084, China; Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA., Bleimeister IH; Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA; Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, PA 15213, USA., Nguyen EK; Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA; Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, PA 15213, USA., Li J; Department of Anesthesiology, Pain Research Center, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA., Cui AY; Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA., Stratton HJ; Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Smith KM; Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Baccei ML; Department of Anesthesiology, Pain Research Center, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA., Ross SE; Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address: saross@pitt.edu.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2024 Mar 26; Vol. 43 (3), pp. 113829. Date of Electronic Publication: 2024 Feb 28.
DOI:	10.1016/j.celrep.2024.113829
Abstrakt:	The nature of spinal output pathways that convey nociceptive information to the brain has been the subject of controversy. Here, we provide anatomical, molecular, and functional characterizations of two distinct anterolateral pathways: one, ascending in the lateral spinal cord, triggers nociceptive behaviors, and the other one, ascending in the ventral spinal cord, when inhibited, leads to sensorimotor deficits. Moreover, the lateral pathway consists of at least two subtypes. The first is a contralateral pathway that extends to the periaqueductal gray (PAG) and thalamus; the second is a bilateral pathway that projects to the bilateral parabrachial nucleus (PBN). Finally, we present evidence showing that activation of the contralateral pathway is sufficient for defensive behaviors such as running and freezing, whereas the bilateral pathway is sufficient for attending behaviors such as licking and guarding. This work offers insight into the complex organizational logic of the anterolateral system in the mouse. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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