Ethnomedicine, phytochemistry, and pharmacological activities of Uvaria chamae P. Beauv.: A comprehensive review.

Autor: Agbebi EA; Institute for Drug Research and Development, S.E. Bogoro Center, Afe Babalola University, PMB 5454, Ado Ekiti, 360001, Nigeria. emmanuelagbebi96@gmail.com.; Department of Pharmacognosy and Natural Products, College of Pharmacy, Afe Babalola University, PMB 5454, Ado Ekiti, 360001, Nigeria. emmanuelagbebi96@gmail.com., Omotuyi OI; Institute for Drug Research and Development, S.E. Bogoro Center, Afe Babalola University, PMB 5454, Ado Ekiti, 360001, Nigeria.; Department of Pharmacology and Toxicology, College of Pharmacy, Afe Babalola University, PMB 5454, Ado Ekiti, 360001, Nigeria.; Bio-Computing & Drug Research Unit, Mols and Sims, Ado Ekiti, Ekiti State, Nigeria., Oyinloye BE; Institute for Drug Research and Development, S.E. Bogoro Center, Afe Babalola University, PMB 5454, Ado Ekiti, 360001, Nigeria.; Phytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, College of Sciences, Afe Babalola University, PMB 5454, Ado Ekiti, 360001, Nigeria.; Biotechnology and Structural Biology (BSB) Group, Department of Biochemistry and Microbiology, University of Zululand, Kwa-Dlangezwa, 3886, South Africa., Okeke UB; Department of Pharmaceutical and Medicinal Chemistry, College of Pharmacy, Afe Babalola University, PMB 5454, Ado Ekiti, 360001, Nigeria., Apanisile I; Institute for Drug Research and Development, S.E. Bogoro Center, Afe Babalola University, PMB 5454, Ado Ekiti, 360001, Nigeria., Okor B; Institute for Drug Research and Development, S.E. Bogoro Center, Afe Babalola University, PMB 5454, Ado Ekiti, 360001, Nigeria., Adefabijo D; Institute for Drug Research and Development, S.E. Bogoro Center, Afe Babalola University, PMB 5454, Ado Ekiti, 360001, Nigeria.
Jazyk: angličtina
Zdroj: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Aug; Vol. 397 (8), pp. 5421-5436. Date of Electronic Publication: 2024 Feb 29.
DOI: 10.1007/s00210-024-03018-6
Abstrakt: The use of medicinal plants as food and medicine has been a common practice in the world, especially in tropical African countries. One such plant in West Africa is Uvaria chamae, also known as Bush banana, renowned for its diverse ethnomedicinal applications and, more recently, for its pharmacological activities attributed to a rich array of phytochemical constituents. Various parts of the plant have been traditionally employed for the treatment of diverse health issues such as digestive disorders, fever, dysmenorrhea, cancer, wound healing, and many more. To unravel the bioactive compounds responsible for these medicinal properties, a comprehensive phytochemical analysis has been undertaken. Notable isolates include chamanetin, dichamanetin, uvaretin, and uvarinol from different parts of the plant. The pharmacological evaluation of these compounds has revealed significant anticancer and antimicrobial properties. Therefore, this review provides a thorough examination of the phytochemicals derived from Uvaria chamae, detailing their associated pharmacological activities both in vitro and in vivo. The review emphasizes the potential of Uvaria chamae as a valuable source of lead compounds for cancer chemotherapy and antimicrobial drug discovery.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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