Growth hormone treatment in children with short stature: impact of the diagnosis on parents.

Autor:	Witt S; Department of Medical Psychology, Center for Psychosocial Medicine, 37734 University Medical Center Hamburg-Eppendorf , Hamburg, Germany., Bloemeke J; Department of Medical Psychology, Center for Psychosocial Medicine, 37734 University Medical Center Hamburg-Eppendorf , Hamburg, Germany., Bullinger M; Department of Medical Psychology, Center for Psychosocial Medicine, 37734 University Medical Center Hamburg-Eppendorf , Hamburg, Germany., Dörr HG; Clinic for Children and Adolescents, 27168 Erlangen-Nürnberg Universtiy , Erlangen, Germany., Silva N; Department of Medical Psychology, Center for Psychosocial Medicine, 37734 University Medical Center Hamburg-Eppendorf , Hamburg, Germany., Quitmann JH; Department of Medical Psychology, Center for Psychosocial Medicine, 37734 University Medical Center Hamburg-Eppendorf , Hamburg, Germany.
Jazyk:	angličtina
Zdroj:	Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] 2024 Mar 01; Vol. 37 (4), pp. 326-335. Date of Electronic Publication: 2024 Mar 01 (Print Publication: 2024).
DOI:	10.1515/jpem-2023-0420
Abstrakt:	Objectives: This prospective multicenter study aimed (1) to examine changes in parent-reported health-related quality of life (HRQOL) of children with short stature and the effects of the children's condition on parents themselves within the first year of human growth hormone (hGH) treatment and (2) to predict effects on parents based on main and interaction effects of children's HRQOL and increase in height. Methods: A total of 110 parents of children aged 4-18 years, diagnosed with idiopathic growth hormone deficiency, small for gestational age, or idiopathic short stature, were recruited from 11 participating German pediatric endocrinologists and asked to fill out the short stature-specific Quality of Life in Short Stature Youth (QoLISSY) Questionnaire before hGH treatment was initiated and one year later. Results: Negative effects of the children's short stature on the parents decrease over time, independent of diagnosis and treatment status. Furthermore, treatment status and height increase moderated the links between children's improved HRQOL as perceived by their parents and decreased caregiving burden. Conclusions: Based on the children's improved HRQOL and the parent's decrease in caregiving burden, patient-reported outcomes that consider parental and child's perspectives should be considered when deciding on hGH treatment for children. (© 2024 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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