A Comprehensive Prognostic and Immune Infiltration Analysis of RBM4 in Pan-Cancer.

Autor:	Ding JJ; Department of Operating Room, Shanghai East Hospital, School of Medicine, Tongji University, 200120 Shanghai, China., Wu J; Department of Anesthesiology, Shanghai East Hospital, School of Medicine, Tongji University, 200120 Shanghai, China., Bian HL; Department of Operating Room, Shanghai East Hospital, School of Medicine, Tongji University, 200120 Shanghai, China., Zong Y; Department of Nursing, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 200127 Shanghai, China., Lu B; Department of Gastrointestinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, 200120 Shanghai, China., Ni L; Department of Nursing, Shanghai East Hospital, School of Medicine, Tongji University, 200120 Shanghai, China.
Jazyk:	angličtina
Zdroj:	Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2024 Feb 23; Vol. 29 (2), pp. 89.
DOI:	10.31083/j.fbl2902089
Abstrakt:	Background: Aberrant splicing has been closely associated with human cancer, though the precise underlying mechanisms linking the two remain not fully understood. Investigating the role of splicing factors in cancer progression may aid in the development of targeted therapies for dysregulated splicing, thereby opening up new avenues for cancer treatment. RNA-binding motif 4 (RBM4) has been identified as a critical participant in the condensin II complex, which is involved in chromosome condensation and stabilization during mitosis. Its significance in tumors is currently gaining attention. The genetic characteristics of RBM4 suggest its potential to elucidate the malignant progression of tumors in a broader context, encompassing various types of cancer, known as pan-cancer. Methods: This study aims to comprehensively explore the potential function of RBM4 in pan-cancer by leveraging existing databases such as The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx). Results: RBM4 is found to be overexpressed in almost all tumors and exhibits significant prognostic and diagnostic efficacy. The correlation between RBM4 and immune signatures, including immune cell infiltration and immune checkpoint genes, indicates that RBM4 could serve as a guiding factor for immunotherapy. Conclusions: As a member of the pan-oncogene, RBM4 has the potential to become a biomarker and therapeutic target for various malignant tumors, offering novel possibilities for precision medicine. Competing Interests: The authors declare no conflict of interest. (© 2024 The Author(s). Published by IMR Press.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu