Exploring magnesium myristate for its dual functionality as a binder and lubricant in the formulation of tablet.

Autor: Pockle R; Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education & Research, Nehru Nagar, Belagavi - 590010, Karnataka, India., Masareddy R; Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education & Research, Nehru Nagar, Belagavi - 590010, Karnataka, India., Bambulkar V; Koel Colors, Pvt. Ltd., Mumbai, India., Desai R; Koel Colors, Pvt. Ltd., Mumbai, India., Kiran S; Department of Pharmaceutics, KLE College of Pharmacy, KLE Academy of Higher Education & Research, Nehru Nagar, Belagavi - 590010, Karnataka, India.
Jazyk: angličtina
Zdroj: Therapeutic delivery [Ther Deliv] 2024 Apr; Vol. 15 (4), pp. 253-266. Date of Electronic Publication: 2024 Feb 29.
DOI: 10.4155/tde-2023-0101
Abstrakt: Purpose: To explore 'magnesium myristate' for its dual functionality as a lubricant and binder in the formulation of tablets. Methods: Using (DoE), tablet formulations using magnesium myristate and conventional excipients (magnesium stearate and PVP K30) were developed by wet granulation technique. The prepared granules and formulated tablets were evaluated for pre- and post-compression parameters, respectively. Results: Magnesium myristate exhibited excellent flow properties. The optimized formulations containing magnesium myristate exhibited increased hardness and in vitro drug release in comparison to conventional excipients. f 2 similarity index for in vitro drug release showed no significant variations with optimized formulations and with the marketed formulations. Conclusion: Magnesium myristate shows a promising replacement for conventional excipients as both a lubricant and binder in tablet formulation.
Databáze: MEDLINE
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