Identification of new major histocompatibility complex-B Haplotypes in Bangladesh native chickens.

Autor: Ediriweera TK; Department of Bio-AI Convergence, Chungnam National University, Daejeon 34134, Korea., Manjula P; Department of Animal Science, Uva Wellassa University, Badulla 90000, Sri Lanka., Kim J; Division of Animal and Dairy Science, Chungnam National University, Daejeon 34134, Korea., Kim JH; Division of Animal and Dairy Science, Chungnam National University, Daejeon 34134, Korea., Nam S; Division of Animal and Dairy Science, Chungnam National University, Daejeon 34134, Korea., Kim M; Division of Animal and Dairy Science, Chungnam National University, Daejeon 34134, Korea., Cho E; Department of Bio-AI Convergence, Chungnam National University, Daejeon 34134, Korea., Bhuiyan MSA; Department of Animal Breeding and Genetics, Bangladesh Agricultural University, Mymensingh-2202, Bangladesh., Rashid MA; Poultry Production Research Division, Bangladesh Livestock Research Institute, Dhaka-1341, Bangladesh., Lee JH; Department of Bio-AI Convergence, Chungnam National University, Daejeon 34134, Korea.; Division of Animal and Dairy Science, Chungnam National University, Daejeon 34134, Korea.
Jazyk: angličtina
Zdroj: Animal bioscience [Anim Biosci] 2024 May; Vol. 37 (5), pp. 826-831. Date of Electronic Publication: 2024 Feb 23.
DOI: 10.5713/ab.23.0295
Abstrakt: Objective: The major histocompatibility complex in chicken demonstrates a great range of variations within varities, breeds, populations and that can eventually influence their immuneresponses. The preset study was conducted to understand the major histocompatibility complex-B (MHC-B) variability in five major populations of Bangladesh native chicken: Aseel, Hilly, Junglefowl, Non-descript Deshi, and Naked Neck.
Methods: These five major populations of Bangladesh native chicken were analyzed with a subset of 89 single nucleotide polymorphisms (SNPs) in the high-density MHC-B SNP panel and Kompetitive Allele-Specific polymerase chain reaction genotyping was applied. To explore haplotype diversity within these populations, the results were analyzed both manually and computationally using PHASE 2.1 program. The phylogenetic investigations were also performed using MrBayes program.
Results: A total of 136 unique haplotypes were identified within these five Bangladesh chicken populations, and only one was shared (between Hilly and Naked Neck). Phylogenetic analysis showed no distinct haplotype clustering among the five populations, although they were shared in distinct clades; notably, the first clade lacked Naked Neck haplotypes.
Conclusion: The present study discovered a set of unique MHC-B haplotypes in Bangladesh chickens that could possibly cause varied immune reponses. However, further investigations are required to evaluate their relationships with global chicken populations.
Databáze: MEDLINE
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