Neuronal dynamics direct cerebrospinal fluid perfusion and brain clearance.

Autor: Jiang-Xie LF; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA. li-feng@wustl.edu.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA. li-feng@wustl.edu., Drieu A; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Bhasiin K; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Quintero D; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Smirnov I; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA., Kipnis J; Brain Immunology and Glia (BIG) Center, Washington University in St Louis, St Louis, MO, USA. kipnis@wustl.edu.; Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, St Louis, MO, USA. kipnis@wustl.edu.
Jazyk: angličtina
Zdroj: Nature [Nature] 2024 Mar; Vol. 627 (8002), pp. 157-164. Date of Electronic Publication: 2024 Feb 28.
DOI: 10.1038/s41586-024-07108-6
Abstrakt: The accumulation of metabolic waste is a leading cause of numerous neurological disorders, yet we still have only limited knowledge of how the brain performs self-cleansing. Here we demonstrate that neural networks synchronize individual action potentials to create large-amplitude, rhythmic and self-perpetuating ionic waves in the interstitial fluid of the brain. These waves are a plausible mechanism to explain the correlated potentiation of the glymphatic flow 1,2 through the brain parenchyma. Chemogenetic flattening of these high-energy ionic waves largely impeded cerebrospinal fluid infiltration into and clearance of molecules from the brain parenchyma. Notably, synthesized waves generated through transcranial optogenetic stimulation substantially potentiated cerebrospinal fluid-to-interstitial fluid perfusion. Our study demonstrates that neurons serve as master organizers for brain clearance. This fundamental principle introduces a new theoretical framework for the functioning of macroscopic brain waves.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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