Atypical memory B cell frequency correlates with antibody breadth and function in malaria immune adults.

Autor: Partey FD; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana. fpartey@noguchi.ug.edu.gh., Dowuona JNN; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Pobee ANA; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Walker MR; Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Aculley B; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Prah DA; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Legon, Ghana., Ofori MF; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana., Barfod LK; Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Feb 28; Vol. 14 (1), pp. 4888. Date of Electronic Publication: 2024 Feb 28.
DOI: 10.1038/s41598-024-55206-2
Abstrakt: Clinical immunity to malaria develops slowly after repeated episodes of infection and antibodies are essential in naturally acquired immunity against malaria. However, chronic exposure to malaria has been linked to perturbation in B-cell homeostasis with the accumulation of atypical memory B cells. It is unclear how perturbations in B cell subsets influence antibody breadth, avidity, and function in individuals naturally exposed to malaria. We show that individuals living in high malaria transmission regions in Ghana have higher Plasmodium falciparum merozoite antigen-specific antibodies and an increased antibody breadth score but lower antibody avidities relative to low transmission regions. The frequency of circulating atypical memory B cells is positively associated with an individual's antibody breadth. In vitro growth inhibition is independent of the ability to bind to free merozoites but associated with the breadth of antibody reactivity in an individual. Taken together, our data shows that repeated malaria episodes hamper the development of high avid antibodies which is compensated for by an increase in antibody breadth. Our results provide evidence to reinforce the idea that in regions with high malaria prevalence, repeated malaria infections lead to the broadening of antibody diversity and the continued presence of atypical memory B cell populations.
(© 2024. The Author(s).)
Databáze: MEDLINE
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