Recent Advancements in Continuous-Flow Suzuki-Miyaura Coupling Utilizing Immobilized Molecular Palladium Complexes.

Autor: Zhang Z; RIKEN Center for Sustainable Resource Science Hirosawa, Wako, Saitama, 351-0198, Japan., Yamada YMA; RIKEN Center for Sustainable Resource Science Hirosawa, Wako, Saitama, 351-0198, Japan.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 May 14; Vol. 30 (27), pp. e202304335. Date of Electronic Publication: 2024 Apr 10.
DOI: 10.1002/chem.202304335
Abstrakt: Immobilized Pd-catalyzed Suzuki-Miyaura coupling under continuous-flow conditions using a packed-bed reactor, representing an efficient, automated, practical, and safe technology compared to conventional batch-type reactions. The core objective of this study is the development of an active and durable catalyst. In contrast to supported Pd nanoparticles, the attachment of Pd complexes onto solid supports through well-defined coordination sites is considered a favorable approach for preparing highly dispersed and stabilized Pd species. These species can be directly employed in various flow reactions without the need for pre-treatment. This concept paper explores recent achievements involving the application of immobilized Pd complexes as precatalysts for continuous-flow Suzuki-Miyaura coupling. Our focus is to elucidate the significance of the designed catalyst structures in relation to their catalytic performance under flow conditions. Additionally, we highlight various reaction systems and catalyst packing methods, emphasizing their crucial roles in establishing a practical synthesis process.
(© 2024 Wiley-VCH GmbH.)
Databáze: MEDLINE
Externí odkaz: