Preliminary evaluation of a commercial shampoo and fine bubble bathing in the treatment of canine atopic dermatitis: A single-blinded, randomised, controlled study.

Autor: Taguchi N; Dermatological and Laboratory Service for Animals, Vet Derm Tokyo, Fujisawa, Kanagawa, Japan., Onishi I; Dermatological and Laboratory Service for Animals, Vet Derm Tokyo, Fujisawa, Kanagawa, Japan., Iyori K; Dermatological and Laboratory Service for Animals, Vet Derm Tokyo, Fujisawa, Kanagawa, Japan., Hsiao YH; Dermatological and Laboratory Service for Animals, Vet Derm Tokyo, Fujisawa, Kanagawa, Japan.
Jazyk: angličtina
Zdroj: Veterinary dermatology [Vet Dermatol] 2024 Aug; Vol. 35 (4), pp. 400-407. Date of Electronic Publication: 2024 Feb 28.
DOI: 10.1111/vde.13245
Abstrakt: Background: Fine bubble (FB) bathing has shown benefits on a mouse model of atopic dermatitis (AD). However, its efficacy in dogs with AD remains to be evaluated.
Objective: This study aimed to assess the clinical effectiveness of FB bathing in dogs with AD.
Animals: Seventeen dogs with AD whose clinical presentation showed a Canine Atopic Dermatitis Extent and Severity Index, 4th iteration (CADESI-04) score of <40.
Materials and Methods: The dogs were randomly assigned to either the FB bathing group or the shampoo group. The treatments were administered once a week as per the instructions, in a trial totalling 4 weeks. Evaluations were conducted on Day (D)0 and D28 to assess the outcomes of the trial. The severity of AD was measured using the CADESI-04 and the pruritus Visual Analog Scale (PVAS). The skin barrier function parameters, transepidermal water loss (TEWL) and stratum corneum hydration were measured before and after the treatment.
Results: Both treatment groups demonstrated a decreasing trend in CADESI-04 scores, yet the FB group exhibited significant improvement in comparison to the shampoo group after 1 month of trial. There were no significant changes in PVAS scores in either group. No significant difference was found in skin barrier function parameters between the two treatments, although TEWL slightly decreased in the FB group and slightly increased in the shampoo group after treatment.
Conclusions and Clinical Relevance: These results suggested that FB treatment provides benefits for dogs with AD and offers an alternative topical treatment option with a lesser impact on skin barrier function compared to frequent shampooing.
(© 2024 Vet Derm Tokyo Dermatological and Laboratory Service for Animals. Veterinary Dermatology published by John Wiley & Sons Ltd on behalf of ESVD and ACVD.)
Databáze: MEDLINE
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