Clinical, pathologic, and molecular characterization of a non-metastatic multicentric cutaneous mast cell tumor in a cow.

Autor: Chevallier L; INSERM, UPEC, Ecole nationale vétérinaire d'Alfort, U955-IMRB, Team 10 - Biology of the Neuromuscular System, Maisons-Alfort, France., Briand A; Ecole Nationale Vétérinaire d'Alfort, CHUV-Animaux de Compagnie, Unité de Dermatologie, Maisons-Alfort, France., Reyes-Gomez E; INSERM, UPEC, Ecole nationale vétérinaire d'Alfort, U955-IMRB, Team 10 - Biology of the Neuromuscular System, Maisons-Alfort, France.; Ecole Nationale Vétérinaire d'Alfort, Biopôle Alfort, Laboratoire d'anatomo-Cytopathologie, Maisons-Alfort, France., Defer W; Ecole Nationale Vétérinaire d'Alfort, CHUV-Animaux de Production, Maisons-Alfort, France., Millemann Y; Ecole Nationale Vétérinaire d'Alfort, CHUV-Animaux de Production, Maisons-Alfort, France.; ANSES, Laboratoire de Sécurité des Aliments, Maisons-Alfort, France., Béguin J; Department of Internal Medicine, Ecole Nationale Vétérinaire d'Alfort, CHUV-Animaux de Compagnie, Maisons-Alfort, France.; INRAE, ANSES, Ecole nationale vétérinaire d'Alfort, UMR Virologie, Maisons-Alfort, France.
Jazyk: angličtina
Zdroj: Veterinary clinical pathology [Vet Clin Pathol] 2024 Mar; Vol. 53 (1), pp. 131-135. Date of Electronic Publication: 2024 Feb 28.
DOI: 10.1111/vcp.13336
Abstrakt: Cutaneous mast cell tumors are rarely reported in cattle. Although mutations in the c-KIT gene have been shown to play a central role in the oncogenesis of canine mast cell tumors, few data are available in cattle. This report describes the clinical, histologic, immunohistochemical, and genetic features of a multicentric cutaneous mast cell tumor in an adult cow. An 11-year-old Prim'Holstein cow was presented for a 5-month history of multiple skin nodules. Cytologic and histologic analyses of the nodules led to a diagnosis of mast cell tumors. Immunohistochemical analysis for KIT expression showed a moderate to strong signal in neoplastic mast cells with a cytoplasmic and membranous pattern. Sequencing of the c-KIT gene coding sequence revealed no mutation. Despite partial response after corticosteroid treatment, euthanasia was elected. No metastases to the lymph nodes, spleen, and liver were identified at post-mortem and histologic examinations.
(© 2024 The Authors. Veterinary Clinical Pathology published by Wiley Periodicals LLC on behalf of American Society for Veterinary Clinical Pathology.)
Databáze: MEDLINE
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