Crown-ether threaded covalent organic polyrotaxane framework (COPF) towards synergistic crown/Zn 2+ /photothermal/photodynamic antibacterial and infected wound healing therapy.

Autor: Wang S; School of Pharmacy, Shandong Second Medical University, Weifang, Shandong 261053, PR China., Zhang J; The First Affiliated Hospital of Shandong Second Medical University (Weifang People's Hospital), Shandong Second Medical University, Weifang, 261044, Shandong, PR China., Chu L; The First Affiliated Hospital of Shandong Second Medical University (Weifang People's Hospital), Shandong Second Medical University, Weifang, 261044, Shandong, PR China., Xiao H; The First Affiliated Hospital of Shandong Second Medical University (Weifang People's Hospital), Shandong Second Medical University, Weifang, 261044, Shandong, PR China., Miao C; School of Pharmacy, Shandong Second Medical University, Weifang, Shandong 261053, PR China., Pan Z; The First Affiliated Hospital of Shandong Second Medical University (Weifang People's Hospital), Shandong Second Medical University, Weifang, 261044, Shandong, PR China., Qiao Y; School of Pharmacy, Shandong Second Medical University, Weifang, Shandong 261053, PR China., Wang Z; School of Pharmacy, Shandong Second Medical University, Weifang, Shandong 261053, PR China. Electronic address: zengyao@wfmc.edu.cn., Zhou B; School of Pharmacy, Shandong Second Medical University, Weifang, Shandong 261053, PR China. Electronic address: zhoubaolong@wfmc.edu.cn.
Jazyk: angličtina
Zdroj: Biomaterials advances [Biomater Adv] 2024 May; Vol. 159, pp. 213814. Date of Electronic Publication: 2024 Feb 26.
DOI: 10.1016/j.bioadv.2024.213814
Abstrakt: Controllable preparation of materials with new structure has always been the top priority of polymer materials science research. Here, the supramolecular binding strategy is adopted to develop covalent organic frameworks (COFs) with novel structures and functions. Based on this, a two-dimensional crown-ether ring threaded covalent organic framework (COF), denoted as Crown-COPF with intrinsic photothermal (PTT) and photodynamic (PDT) therapeutic capacity, was facilely developed using crown-ether threaded rotaxane and porphyrin as building blocks. Crown-COPF with discrete mechanically interlocked blocks in the open pore could be used as a molecular machine, in which crown-ether served as the wheel sliding along the axle under the laser stimulation. As a result, Crown-COPF combining with the bactericidal power of crown ether displayed a significant photothermal and photodynamic antibacterial activity towards both the Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus), far exceeding the traditional Crown-free COF. Noteworthily, the bactericidal performance could be further enhanced via impregnation of Zn 2+ ions (Crown-COPF-Zn) flexible coordinated with the multiple coordination sites (crown-ether, bipyridine, and porphyrin), which not only endow the positive charge with the skeleton, enhancing its ability to bind to the bacterial membrane, but also introduce the bactericidal ability of zinc ions. Notably, in vivo experiments on mice with back infections indicates Crown-COPF-Zn with self-adaptive multinuclear zinc center, could effectively promote the repairing of wounds. This study paves a new avenue for the effectively preparation of porous polymers with brand new structure, which provides opportunities for COF and mechanically interlocked polymers (MIPs) research and applications.
Competing Interests: Declaration of competing interest The authors state that there is no conflict of interest.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
Externí odkaz: