Metal-free synthesis of propargylamines via light-mediated persulfate activation and phase-transfer catalysis.

Autor:	Zaragoza CAD; Department of Organic Chemistry, Institute of Chemistry, University of Campinas, P.O. Box 6154, Campinas, SP 13084-862, Brazil. hoffman@unicamp.br., Peagno GSG; Department of Organic Chemistry, Institute of Chemistry, University of Campinas, P.O. Box 6154, Campinas, SP 13084-862, Brazil. hoffman@unicamp.br., Minguine AJA; Department of Organic Chemistry, Institute of Chemistry, University of Campinas, P.O. Box 6154, Campinas, SP 13084-862, Brazil. hoffman@unicamp.br., Salles AG Jr; Department of Organic Chemistry, Institute of Chemistry, University of Campinas, P.O. Box 6154, Campinas, SP 13084-862, Brazil. hoffman@unicamp.br.
Jazyk:	angličtina
Zdroj:	Organic & biomolecular chemistry [Org Biomol Chem] 2024 Mar 20; Vol. 22 (12), pp. 2359-2364. Date of Electronic Publication: 2024 Mar 20.
DOI:	10.1039/d4ob00218k
Abstrakt:	We present a metal-free method to synthesize secondary and tertiary propargylamines from primary and secondary amines and alkynes using light-mediated persulfate activation and phase-transfer catalysis. Our method explores a tandem oxidative coupling/alkynylation reaction for the generation of diverse compounds, highlighting the sustainability of the process and its wide scope.
Databáze:	MEDLINE
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