Clinical isolates of Streptococcus mitis/oralis -related species with reduced carbapenem susceptibility, harboring amino acid substitutions in penicillin-binding proteins in Japan.

Autor:	Sarangi J; Department of Bacteriology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Ido A; Department of Bacteriology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Ito M; Department of Bacteriology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Iinuma C; Department of Bacteriology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Doyama Y; Department of Bacteriology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Jin W; Department of Bacteriology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Wachino J-i; Department of Bacteriology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Suzuki M; Department of Microbiology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan., Iguchi M; Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Nagoya, Japan., Yagi T; Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Nagoya, Japan., Arakawa Y; Department of Bacteriology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Kimura K; Department of Bacteriology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Jazyk:	angličtina
Zdroj:	Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Apr 03; Vol. 68 (4), pp. e0117923. Date of Electronic Publication: 2024 Feb 28.
DOI:	10.1128/aac.01179-23
Abstrakt:	Streptococcus mitis/oralis group isolates with reduced carbapenem susceptibility have been reported, but its isolation rate in Japan is unknown. We collected 356 clinical α-hemolytic streptococcal isolates and identified 142 of them as S. mitis/oralis using partial sodA sequencing. The rate of meropenem non-susceptibility was 17.6% (25/142). All 25 carbapenem-non-susceptible isolates harbored amino acid substitutions in/near the conserved motifs in PBP1A, PBP2B, and PBP2X. Carbapenem non-susceptibility is common among S. mitis/oralis group isolates in Japan. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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