Identification of a strong genetic risk factor for major depressive disorder in the human virome.

Autor:	Kobayashi N; Department of Virology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan., Shimada K; Department of Virology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan., Ishii A; Department of Virology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan., Osaka R; Department of Virology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan., Nishiyama T; Department of Public Health & Environmental Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan., Shigeta M; Department of Psychiatry, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan., Yanagisawa H; Department of Public Health & Environmental Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan., Oka N; Department of Virology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan., Kondo K; Department of Virology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2024 Feb 10; Vol. 27 (3), pp. 109203. Date of Electronic Publication: 2024 Feb 10 (Print Publication: 2024).
DOI:	10.1016/j.isci.2024.109203
Abstrakt:	The heritability of major depressive disorder (MDD) is reportedly 30-50%. However, the genetic basis of its heritability remains unknown. Within SITH-1, a risk factor for MDD in human herpesvirus 6B (HHV-6B), we discovered a gene polymorphism with a large odds ratio for an association with MDD. It was a sequence whose number of repeats was inversely correlated with SITH-1 expression. This number was significantly lower in MDD patients. Rates for 17 or fewer repeats of the sequence were 67.9% for MDD and 28.6% for normal controls, with an odds ratio of 5.28. For patients with 17 or less repeats, the rate for presence of another MDD patient in their families was 47.4%, whereas there were no MDD patients in the families of patients with more than 17 repeats. Since HHV-6B is transmitted primarily mother to child and within families and persists for life, this gene polymorphism could potentially influence heritability of MDD. Competing Interests: K.K. and N.K. have submitted a patent application entitled “Factor involved in latent infection with herpesvirus, and use thereof,” US patent application publication 2010/0281550 A1. N.O., K.K., and N.K. have submitted a patent application entitled “Method for detecting antibody against SITH-1 in biological sample,” US patent application publication 2012/0107842 A1. K.K. has stock in Virus Ikagaku Kenkyusho Inc. (© 2024 The Author(s).)
Databáze:	MEDLINE
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