Association of Dental Caries in Primary Teeth With HLA Class II Gene Among Syrian Children.
| Autor: | Malas N; Pediatric Dentistry, Damascus University, Damascus, SYR., Kochaji C; Pediatric Dentistry, Damascus University, Damascus, SYR., Soukkarieh C; Animal Science, Damascus University, Damascus, SYR., Almonakel MB; Pediatric Dentistry, Damascus University, Damascus, SYR., Alzoubi H; Pediatric Dentistry, Damascus University, Damascus, SYR. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Jan 27; Vol. 16 (1), pp. e53081. Date of Electronic Publication: 2024 Jan 27 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.53081 |
| Abstrakt: | Background and objectives Numerous studies have shown that there is evidence that genetic factors contribute in different ways to the occurrence of caries lesions, and the multiple differences in the human leucocytes antigen (HLA) gene patterns play an important role in the body's immune response. Therefore, this study aimed to evaluate the association between some HLA class II alleles (HLA-DR4, HLA-DQ2, HLA-DQ4) and early childhood caries (ECC) occurrence in Syrian children. Materials and methods The study included 80 children aged three to six, divided into two groups: Group 1 (n = 40) being severe early childhood caries (S-ECC) children (deft ≥ 10) and Group 2 (n = 40) being free caries children (deft = 0). The genomic DNAs were extracted and collected by taking a buccal swab using a sterile metal strip and were amplified by polymerase chain reaction-single specific primer (PCR-SSP) and then HLA-typing was performed for all alleles. Results There were no statistically significant differences in the frequency of occurrence of S-ECC, HLA-DR4, and HLA-DQ2 alleles (p = 0.626, 0.256 respectively), while the incidence of S-ECC was associated with the DQ4 allele (p = 0.012). Conclusion HLA class II molecules may play a crucial role in predisposing to ECC, since positive HLA-DQ4 may enhance the chance of developing ECC. However, no association were found between (HLA-DR4 and HLA-DQ2) and ECC. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Malas et al.) |
| Databáze: | MEDLINE |
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