Correlation of Grades of Non-alcoholic Fatty Liver on Ultrasound With Blood Parameters.

Autor:	Zafar U; Radiology, Aga Khan University Hospital, Karachi, PAK., Ahmad MN; Radiology, Aga Khan University Hospital, Karachi, PAK., Nadeem N; Radiology, Aga Khan University Hospital, Karachi, PAK., Muhammad Zohaib Uddin M; Radiology, Aga Khan University Hospital, Karachi, PAK., Zafar B; Radiology, Aga Khan University Hospital, Karachi, PAK., Baig S; Radiology, Aga Khan University Hospital, Karachi, PAK., Zafar F; Epidemiology and Public Health, Quaid-e-Azam Medical College, Bahawalpur, PAK., Pervez H; Internal Medicine, Dow University of Health Sciences, Civil Hospital Karachi, Karachi, PAK., Akram S; Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, PAK.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jan 27; Vol. 16 (1), pp. e53075. Date of Electronic Publication: 2024 Jan 27 (Print Publication: 2024).
DOI:	10.7759/cureus.53075
Abstrakt:	Introduction Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver condition worldwide. NAFLD has been associated with metabolic syndrome and its symptoms, such as type 2 diabetes, hypertension, dyslipidemia, and obesity. Ultrasound is widely used to grade hepatic steatosis, being the most cost-effective, non-invasive, and readily available modality without radiation exposure. The study aimed to assess the correlation of NAFLD grade as seen on ultrasound with blood parameters in a Pakistani population. Materials and methods The included patients were those who were diagnosed with fatty liver disease on ultrasound and whose laboratory tests were available within two weeks of the ultrasound. Two seasoned radiologists rated the severity of NAFLD after looking over ultrasound scans. Consecutive sampling technique was used to minimize selection bias. The degree and direction of the linear relationship between the NAFLD grade and each biochemical parameter were measured using the Pearson correlation coefficient. Results There were 207 patients in all who had been identified with NAFLD on ultrasound, the majority of whom had grade II NAFLD and were in their sixth decade of life. According to Pearson's analysis, the grade of NAFLD had larger positive associations with triglycerides, total cholesterol, low-density lipoprotein, and fasting blood sugar. High density lipoprotein and C-reactive protein were found to have a negative correlation with the grade of NAFLD. Conclusion The findings of the study highlight the correlation between NAFLD grade on ultrasonography and specific blood parameters, implying that managing these biochemical indicators may help to improve hepatic steatosis. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Zafar et al.)
Databáze:	MEDLINE
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