Reduction of Pro-Inflammatory Markers in RAW264.7 Macrophages by Polyethylenimines.

Autor: Frisch E; 3Bio Team, CAMB UMR7199, Faculté de Pharmacie, CNRS-Université de Strasbourg, 74 route du Rhin, Illkirch Cedex, F-67401, France.; Inserm UMR_S 1121, EMR 7003 CNRS, Biomaterials and Bioengineering, Centre de Recherche en Biomédecine de Strasbourg, Université de Strasbourg, 1 rue Eugène Boeckel, Strasbourg, F-67000, France., Dussouillez C; 3Bio Team, CAMB UMR7199, Faculté de Pharmacie, CNRS-Université de Strasbourg, 74 route du Rhin, Illkirch Cedex, F-67401, France.; Inserm UMR_S 1121, EMR 7003 CNRS, Biomaterials and Bioengineering, Centre de Recherche en Biomédecine de Strasbourg, Université de Strasbourg, 1 rue Eugène Boeckel, Strasbourg, F-67000, France., McCartin C; 3Bio Team, CAMB UMR7199, Faculté de Pharmacie, CNRS-Université de Strasbourg, 74 route du Rhin, Illkirch Cedex, F-67401, France., Blumberger J; 3Bio Team, CAMB UMR7199, Faculté de Pharmacie, CNRS-Université de Strasbourg, 74 route du Rhin, Illkirch Cedex, F-67401, France., Humbert C; 3Bio Team, CAMB UMR7199, Faculté de Pharmacie, CNRS-Université de Strasbourg, 74 route du Rhin, Illkirch Cedex, F-67401, France., Lebeau L; V-SAT Team, Laboratoire de Conception et Application de Molécules Bioactives, UMR 7199, Faculté de Pharmacie, CNRS-Université de Strasbourg, Illkirch, F-67401, France., Frisch B; 3Bio Team, CAMB UMR7199, Faculté de Pharmacie, CNRS-Université de Strasbourg, 74 route du Rhin, Illkirch Cedex, F-67401, France.; Inserm UMR_S 1121, EMR 7003 CNRS, Biomaterials and Bioengineering, Centre de Recherche en Biomédecine de Strasbourg, Université de Strasbourg, 1 rue Eugène Boeckel, Strasbourg, F-67000, France., Heurtault B; 3Bio Team, CAMB UMR7199, Faculté de Pharmacie, CNRS-Université de Strasbourg, 74 route du Rhin, Illkirch Cedex, F-67401, France.; Inserm UMR_S 1121, EMR 7003 CNRS, Biomaterials and Bioengineering, Centre de Recherche en Biomédecine de Strasbourg, Université de Strasbourg, 1 rue Eugène Boeckel, Strasbourg, F-67000, France., Kichler A; 3Bio Team, CAMB UMR7199, Faculté de Pharmacie, CNRS-Université de Strasbourg, 74 route du Rhin, Illkirch Cedex, F-67401, France.; Inserm UMR_S 1121, EMR 7003 CNRS, Biomaterials and Bioengineering, Centre de Recherche en Biomédecine de Strasbourg, Université de Strasbourg, 1 rue Eugène Boeckel, Strasbourg, F-67000, France., Fournel S; 3Bio Team, CAMB UMR7199, Faculté de Pharmacie, CNRS-Université de Strasbourg, 74 route du Rhin, Illkirch Cedex, F-67401, France.; Inserm UMR_S 1121, EMR 7003 CNRS, Biomaterials and Bioengineering, Centre de Recherche en Biomédecine de Strasbourg, Université de Strasbourg, 1 rue Eugène Boeckel, Strasbourg, F-67000, France.
Jazyk: angličtina
Zdroj: Macromolecular bioscience [Macromol Biosci] 2024 Jun; Vol. 24 (6), pp. e2300492. Date of Electronic Publication: 2024 Mar 07.
DOI: 10.1002/mabi.202300492
Abstrakt: The physiological problem of chronic inflammation and its associated pathologies attract ongoing attention with regard to methods for their control. Current systemic pharmacological treatments present problematic side effects. Thus, the possibility of new anti-inflammatory compounds with differing mechanisms of action or biophysical properties is enticing. Cationic polymers, with their ability to act as carriers for other molecules or to form bio-compatible materials, present one such possibility. Although not well described, several polycations such as chitosan and polyarginine, have displayed anti-inflammatory properties. The present work shows the ubiquitous laboratory transfection reagent, polyethylenimine (PEI) and more specifically low molecular weight branched PEI (B-PEI) as also possessing such properties. Using a RAW264.7 murine cell line macrophage as an inflammation model, it is found the B-PEI 700 Da as being capable of reducing the production of several pro-inflammatory molecules induced by the endotoxin lipopolysaccharide. Although further studies are required for elucidation of its mechanisms, the revelation that such a common lab reagent may present these effects has wide-ranging implications, as well as an abundance of possibilities.
(© 2024 The Authors. Macromolecular Bioscience published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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