Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases.

Autor: Shek N; Systems Medicine, School of Medicine, University of Dundee, Dundee, UK., Choy AM; Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK., Lang CC; Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK., Miller BE; COPD Foundation, Miami, USA., Tal-Singer R; Global Allergy and Airways Patient Platform, Vienna, Austria., Bolton CE; Centre for Respiratory Research, NIHR Nottingham Biomedical Research Centre, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK., Thomson NC; School of Infection and immunity, University of Glasgow, Glasgow, Scotland, UK., Chalmers JD; Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK., Bown MJ; Department of Cardiovascular Sciences and NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK., Newby DE; MRC / University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, Scotland, UK., Khan F; Systems Medicine, School of Medicine, University of Dundee, Dundee, UK., Huang JTJ; Systems Medicine, School of Medicine, University of Dundee, Dundee, UK. jtjhuang@dundee.ac.uk.
Jazyk: angličtina
Zdroj: Npj aging [NPJ Aging] 2024 Feb 27; Vol. 10 (1), pp. 15. Date of Electronic Publication: 2024 Feb 27.
DOI: 10.1038/s41514-024-00143-7
Abstrakt: Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.
(© 2024. The Author(s).)
Databáze: MEDLINE
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