Hookworm infection as a model for deepen knowledge of iron metabolism and erythropoiesis in anemia.

Autor: Furtado LFV; Universidade Federal de Minas Gerais, Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Avenida Presidente Antônio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte, Minas Gerais, Brazil. Electronic address: lfvfurtado@farmacia.ufmg.br., Alves WP; Universidade Federal de Minas Gerais, Hospital das Clínicas, Avenida Professor Alfredo Balena, 110, Santa Efigênia, CEP 30130-100 Belo Horizonte, Minas Gerais, Brazil., da Silva VJ; Prefeitura Municipal de Sabará, Centro de Controle de Zoonoses, Avenida Charles Gonort, CEP: 34505620, Rosario I, Sabará, Minas Gerais, Brazil., Rabelo ÉML; Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Parasitologia, Avenida Presidente Antônio Carlos, 6627, Pampulha, CEP 31270-901 Belo Horizonte, Minas Gerais, Brazil.
Jazyk: angličtina
Zdroj: Cytokine [Cytokine] 2024 May; Vol. 177, pp. 156559. Date of Electronic Publication: 2024 Feb 27.
DOI: 10.1016/j.cyto.2024.156559
Abstrakt: Over the years, there has been progress in understanding the molecular aspects of iron metabolism and erythropoiesis. However, despite research conducted both in laboratories and living organisms, there are still unanswered questions due to the complex nature of these fields. In this study we investigated the effects of hookworm infection on iron metabolism and how the hosts response to anemia is affected using hamsters infected with Ancylostoma ceylanicum as a model. Our data revealed interesting relationships between infection-induced anemia, erythropoiesis, iron metabolism, and immune modulation, such that the elevated production of erythropoietin (EPO) in renal tissue indicated intensified erythropoiesis in response to anemia. Additionally, the increased expression of the erythroferrone (ERFE) gene in the spleen suggested its involvement in iron regulation and erythropoiesis. Gene expression patterns of genes related to iron metabolism varied in different tissues, indicating tissue-specific adaptations to hypoxia. The modulation of pro-inflammatory and anti-inflammatory cytokines highlighted the delicate balance between immune response and erythropoiesis. Data derived from the investigation of changes induced in iron metabolism and stress erythropoiesis following anemia aid in our understanding of mechanisms related to blood spoliation and anemia, which could potentially be extrapolated or compared to other types or causes of anemia. These findings also contribute to our understanding of the pathophysiology of erythropoiesis in the context of blood loss.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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