Assessment of gait mechanics and muscle strength in hypermobile Ehlers Danlos Syndrome.

Autor: Ball LN; Department of Kinesiology and Health Promotion, University of Kentucky, Lexington, KY, USA. Electronic address: linball93@gmail.com., Jacobs MV; Department of Kinesiology and Health Promotion, University of Kentucky, Lexington, KY, USA., McLouth CJ; Department of Biostatistics, University of Kentucky, Lexington, KY, USA., Clasey J; Department of Kinesiology and Health Promotion, University of Kentucky, Lexington, KY, USA., Francomano C; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA., Sheppard MB; Department of Family and Community Medicine, Surgery, and Physiology, University of Kentucky, Lexington, KY, USA; Saha Aortic Center and Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, USA., Samaan MA; Department of Kinesiology and Health Promotion, University of Kentucky, Lexington, KY, USA.
Jazyk: angličtina
Zdroj: Clinical biomechanics (Bristol, Avon) [Clin Biomech (Bristol, Avon)] 2024 Mar; Vol. 113, pp. 106210. Date of Electronic Publication: 2024 Feb 18.
DOI: 10.1016/j.clinbiomech.2024.106210
Abstrakt: Background: Hypermobile Ehlers Danlos Syndrome, a heritable connective tissue disorder, is associated with muscle dysfunction, joint subluxations and pain. The impact of hypermobile Ehlers Danlos Syndrome on musculoskeletal mechanics is understudied. Therefore, the aim of this study was to assess the effects of hypermobile Ehlers Danlos Syndrome on lower extremity gait mechanics and muscle strength.
Methods: Eleven people with hypermobile Ehlers Danlos Syndrome and 11 asymptomatic controls underwent a 3D gait analysis and isometric hip and knee muscle strength assessment. Joint subluxations were self-reported by the hypermobile Ehlers Danlos syndrome group. Independent t-tests and Mann Whitney U tests were used to analyze joint mechanics, muscle strength, and patient report outcomes (p < 0.05).
Findings: Both groups exhibited similar walking speeds as well as similar hip, knee, and ankle joint kinematics. The hypermobile Ehlers Danlos Syndrome group walked with a lower peak hip extensor moment (hypermobile Ehlers Danlos Syndrome: -0.52 ± 0.28 Nmˑkg -1 , Control: -0.83 ± 0.26 Nmˑkg -1 , p = 0.01) yet similar knee and ankle joint moments. The hypermobile Ehlers Danlos Syndrome group exhibited a 40% deficit in peak hip extensor strength (hypermobile Ehlers Danlos Syndrome:1.07 ± 0.53 Nmˑkg -1 , Control: 1.77 ± 0.79 Nmˑkg -1 , p = 0.04). Approximately 73%, 55% and 45% of the hypermobile Ehlers Danlos Syndrome cohort self-reported hip, knee/patella and ankle joint subluxations, respectively, at least once a week.
Interpretation: Patients with hypermobile Ehlers Danlos Syndrome ambulated with altered hip extensor moments and exhibit hip extensor weakness. Future work should investigate the underlying mechanisms of hip extensor weakness and corresponding effects on joint health in people with hypermobile Ehlers Danlos Syndrome.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
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