Osteo-inductive effect of piezoelectric stimulation from the poly(l-lactic acid) scaffolds.

Autor: Das R; Department of Biomedical Engineering, University of Connecticut, School of Engineering, Storrs, CT, United States of America.; National Institute of Biomedical Imaging and Bioengineering, National Institute of Health, Bethesda, MD, United States of America., Le D; Department of Mechanical Engineering, University of Connecticut, School of Engineering, Storrs, CT, United States of America.; Vinmec Research Institute of Stem Cell and Gene Technology, Vinmec Health System, Hanoi, Vietnam, United States of America., Kan HM; The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut, Storrs, CT, United States of America., Le TT; Department of Mechanical Engineering, University of Connecticut, School of Engineering, Storrs, CT, United States of America., Park J; Department of Biomedical Engineering, University of Connecticut, School of Engineering, Storrs, CT, United States of America., Nguyen TD; Department of Biomedical Engineering, University of Connecticut, School of Engineering, Storrs, CT, United States of America.; Department of Mechanical Engineering, University of Connecticut, School of Engineering, Storrs, CT, United States of America.; Institute of Materials Science (IMS), University of Connecticut, School of Engineering, Storrs, CT, United States of America., Lo KW; Department of Biomedical Engineering, University of Connecticut, School of Engineering, Storrs, CT, United States of America.; The Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut, Storrs, CT, United States of America.; Institute of Materials Science (IMS), University of Connecticut, School of Engineering, Storrs, CT, United States of America.; Department of Medicine, Division of Endocrinology, University of Connecticut Health Center, School of Medicine, Farmington, CT, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Feb 27; Vol. 19 (2), pp. e0299579. Date of Electronic Publication: 2024 Feb 27 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0299579
Abstrakt: Piezoelectric biomaterials can generate piezoelectrical charges in response to mechanical activation. These generated charges can directly stimulate bone regeneration by triggering signaling pathway that is important for regulating osteogenesis of cells seeded on the materials. On the other hand, mechanical forces applied to the biomaterials play an important role in bone regeneration through the process called mechanotransduction. While mechanical force and electrical charges are both important contributing factors to bone tissue regeneration, they operate through different underlying mechanisms. The utilizations of piezoelectric biomaterials have been explored to serve as self-charged scaffolds which can promote stem cell differentiation and the formation of functional bone tissues. However, it is still not clear how mechanical activation and electrical charge act together on such a scaffold and which factors play more important role in the piezoelectric stimulation to induce osteogenesis. In our study, we found Poly(l-lactic acid) (PLLA)-based piezoelectric scaffolds with higher piezoelectric charges had a more pronounced osteoinductive effect than those with lower charges. This provided a new mechanistic insight that the observed osteoinductive effect of the piezoelectric PLLA scaffolds is likely due to the piezoelectric stimulation they provide, rather than mechanical stimulation alone. Our findings provide a crucial guide for the optimization of piezoelectric material design and usage.
Competing Interests: Note that Dr. Thanh Nguyen has a conflict of interest with PiezoBioMembrane Inc. and SingleTimeMicroneedles Inc. Dr. Kevin Lo has served as an Associate Editor for PLoS ONE since 2019. We confirm that this does not alter our adherence to PLOS ONE policies on sharing data and materials.
(Copyright: © 2024 Das et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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