The genomic and evolutionary landscapes of anaplastic thyroid carcinoma.

Autor:	Zeng PYF; Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada; London Regional Cancer Program, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada., Prokopec SD; Ontario Institute for Cancer Research, Toronto, ON, Canada; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA., Lai SY; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Pinto N; Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada., Chan-Seng-Yue MA; Ontario Institute for Cancer Research, Toronto, ON, Canada., Clifton-Bligh R; Division of Endocrinology, Royal North Shore Hospital, and University of Sydney, Sydney, NSW, Australia., Williams MD; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Howlett CJ; Department of Pathology, Western University, London, ON, Canada., Plantinga P; Department of Pathology, Western University, London, ON, Canada., Cecchini MJ; Department of Pathology, School of Medicine, Griffith University, Gold Coast, QLD, Australia., Lam AK; Department of Pathology, School of Medicine, Griffith University, Gold Coast, QLD, Australia., Siddiqui I; Department of Laboratory Medicine, Hospital for Sick Children, Toronto, ON, Canada., Wang J; Ontario Institute for Cancer Research, Toronto, ON, Canada., Sun RX; Ontario Institute for Cancer Research, Toronto, ON, Canada., Watson JD; Ontario Institute for Cancer Research, Toronto, ON, Canada; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA., Korah R; Department of Surgery, Yale University, New Haven, CT, USA., Carling T; Department of Surgery, Yale University, New Haven, CT, USA., Agrawal N; Department of Otolaryngology - Head and Neck Surgery, University of Chicago, Chicago, IL, USA., Cipriani N; Department of Pathology, University of Chicago, Chicago, IL, USA., Ball D; Division of Endocrinology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Nelkin B; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA., Rooper LM; Division of Pathology, Johns Hopkins University, Baltimore, MD, USA., Bishop JA; Department of Pathology, University of Texas Southwestern, Dallas, TX, USA., Garnis C; BC Cancer Agency, Vancouver, BC, Canada., Berean K; BC Cancer Agency, Vancouver, BC, Canada., Nicolson NG; Department of Surgery, Yale University, New Haven, CT, USA., Weinberger P; Department of Otolaryngology - Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, USA; Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA, USA., Henderson YC; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lalansingh CM; Ontario Institute for Cancer Research, Toronto, ON, Canada., Tian M; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA., Yamaguchi TN; Ontario Institute for Cancer Research, Toronto, ON, Canada; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA., Livingstone J; Ontario Institute for Cancer Research, Toronto, ON, Canada; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA., Salcedo A; Ontario Institute for Cancer Research, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA., Patel K; Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada; Ontario Institute for Cancer Research, Toronto, ON, Canada., Vizeacoumar F; Cancer Research Cluster, University of Saskatchewan, Saskatoon, SK, Canada., Datti A; Network Biology Collaborative Centre, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada; Department of Agricultural, Food, and Environmental Sciences, University of Perugia, Perugia, Italy., Xi L; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Nikiforov YE; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Smallridge R; Division of Endocrinology, Department of Medicine, Mayo Clinic, Jacksonville, FL, USA., Copland JA; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA., Marlow LA; Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA., Hyrcza MD; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada., Delbridge L; Department of Surgery, Royal North Shore Hospital, Sydney, NSW, Australia; University of Sydney, Sydney, NWS, Australia., Sidhu S; Department of Surgery, Royal North Shore Hospital, Sydney, NSW, Australia; University of Sydney, Sydney, NWS, Australia., Sywak M; Department of Surgery, Royal North Shore Hospital, Sydney, NSW, Australia; University of Sydney, Sydney, NWS, Australia., Robinson B; University of Sydney, Sydney, NWS, Australia; Department of Endocrinology, Royal North Shore Hospital, Sydney, NSW, Australia., Fung K; Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada., Ghasemi F; Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada., Kwan K; Department of Pathology, Western University, London, ON, Canada., MacNeil SD; Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada., Mendez A; Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada., Palma DA; London Regional Cancer Program, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada., Khan MI; Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada., Shaikh M; Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada., Ruicci KM; Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada., Wehrli B; Department of Pathology, Western University, London, ON, Canada., Winquist E; London Regional Cancer Program, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada., Yoo J; Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada., Mymryk JS; Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada; London Regional Cancer Program, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada; Department of Microbiology and Immunology, Western University, London, ON, Canada., Rocco JW; Department of Otolaryngology - Head and Neck Surgery, Ohio State University, Columbus, OH, USA., Wheeler D; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Scherer S; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Giordano TJ; Department of Pathology, University of Michigan, Ann Arbor, MI, USA., Barrett JW; Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada., Faquin WC; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Gill AJ; University of Sydney, Sydney, NWS, Australia; Cancer Diagnosis and Pathology Group, Kolling Institute of Medicine, Royal North Shore Hospital, Sydney, NSW, Australia; NSW Health Pathology, Department of Anatomical Pathology, Royal North Shore Hospital, Sydney, NSW, Australia., Clayman G; The Clayman Thyroid Surgery and Thyroid Cancer Center, The Thyroid Institute, Tampa General Hospital, Tampa, FL, USA., Boutros PC; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA; Department of Urology, University of California, Los Angeles, Los Angeles, CA, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, USA; Institute for Precision Health, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address: pboutros@mednet.ucla.edu., Nichols AC; Department of Otolaryngology - Head and Neck Surgery, Western University, London, ON, Canada; London Regional Cancer Program, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada; Department of Oncology, Western University, London, ON, Canada. Electronic address: anthony.nichols@lhsc.on.ca.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2024 Mar 26; Vol. 43 (3), pp. 113826. Date of Electronic Publication: 2024 Feb 26.
DOI:	10.1016/j.celrep.2024.113826
Abstrakt:	Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated thyroid cancers, yet the molecular origins of its aggressivity are unknown. We sequenced tumor DNA from 329 regions of thyroid cancer, including 213 from patients with primary anaplastic thyroid carcinomas. We also whole genome sequenced 9 patients using multi-region sequencing of both differentiated and anaplastic thyroid cancer components. Using these data, we demonstrate thatanaplastic thyroid carcinomas have a higher burden of mutations than other thyroid cancers, with distinct mutational signatures and molecular subtypes. Further, different cancer driver genes are mutated in anaplastic and differentiated thyroid carcinomas, even those arising in a single patient. Finally, we unambiguously demonstrate that anaplastic thyroid carcinomas share a genomic origin with co-occurring differentiated carcinomas and emerge from a common malignant field through acquisition of characteristic clonal driver mutations. Competing Interests: Declaration of interests All authors declare that they have no competing interests. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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