Assessment of Right Ventricular Systolic Function using Tricuspid Annular Plane Systolic Excursion (TAPSE) among HIV Patients on HAART and Its Relationship with Viral Load and CD4 Cell Count.

Autor:	Baba MM; Department of Medicine, Yobe State University Teaching Hospital Damaturu, Nigeria. Email: drbaba01@gmail.com; Phone: +2348065588144., Buba F; Department of Medicine, College of Medical Sciences, University of Maiduguri, Maiduguri, Nigeria., Talle MA; Department of Medicine, College of Medical Sciences, University of Maiduguri, Maiduguri, Nigeria., Garbati MA; Department of Medicine, College of Medical Sciences, University of Maiduguri, Maiduguri, Nigeria., Abdul H; Department of Medicine, Yobe State University Teaching Hospital Damaturu, Nigeria. Email: drbaba01@gmail.com; Phone: +2348065588144.
Jazyk:	angličtina
Zdroj:	West African journal of medicine [West Afr J Med] 2024 Jan 31; Vol. 41 (1), pp. 25-29.
Abstrakt:	Background: The introduction of highly active antiretroviral therapy (HAART) has decreased the morbidity and mortality associated with HIV infection; however, this survival advantage is not free from complications. HIV patients are more likely to develop cardiovascular disease compared with the general population, and right ventricular systolic dysfunction is said to be associated with worse outcomes. We, therefore, sought to assess right ventricular systolic function using tricuspid annular plain systolic excursion (TAPSE) among HIV patients on HAART and its relationship with viral load and CD4 cell count. Methods: The study was a cross-sectional conducted among HIV patients receiving HAART at the Federal Medical Centre, Nguru, Yobe State, Northeastern Nigeria. Right ventricular systolic function was assessed using tricuspid annular plane systolic excursion. Results: One hundred and seven (107) subjects were recruited into the study comprising thirty-seven (34.6%) males and seventy (65.4%) females. The mean CD4 cell count and viral load of the studied patients were 612.65 ± 347.62 cells/μL and 315.44±271.11copies/mL, respectively. The distribution of RVSF according to CD4 cell count showed, fifteen (14.01%) patients with CD4 cell count less than 250 had reduced right ventricular systolic function (RVSF), 30 (28.03%) patients with CD4 cell count 250 - 500 had reduced RVSF, 1 (0.93%) patient with CD4 cell count 250 - 500 had normal RVSF, 47 (43.92%) patients with CD4 cell count 501 -1,000 had normal RVSF and 14(13.08%) patients with CD4 cell count greater than 1,000 had normal RVSF. Fourteen (13.08%) patients with undetectable viral load had normal RVSF, 47(43.92%) patients with viral load 50 - 1,500 had normal RVSF, 1(0.93%) patient with viral load 1,501 - 10,000 had normal RVSF, 30(28.03%) patients with viral load 1,501 - 10,000 had reduced RVSF and 15(14.01%) patients with viral load 10,000 - 50,000 had reduced RVSF. There was a positive and significant correlation between tricuspid annular plain systolic excursion with CD4 cell count and a negative but significant correlation HIV viral load. Conclusion: We therefore concluded that asymptomatic right ventricular systolic dysfunction exists among patients with HIV infection and there was positive and significant correlation between tricuspid annular plain systolic excursion with CD4 cells count and a negative but significant correlation HIV viral load. Competing Interests: The Authors declare that no competing interest exists. (Copyright © 2024 by West African Journal of Medicine.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu