Environmental exposure to per- and polyfluoroalkyl substances mixture and asthma in adolescents.

Autor: Wang YF; Clinical School of Paediatrics, Tianjin Medical University, Tianjin, China.; Department of Pulmonology, Tianjin Children's Hospital (Children's Hospital of Tianjin University), Machang Compus, 225 Machang Road, Hexi District, Tianjin, 300074, China., Li L; Clinical School of Paediatrics, Tianjin Medical University, Tianjin, China.; Department of Pulmonology, Tianjin Children's Hospital (Children's Hospital of Tianjin University), Machang Compus, 225 Machang Road, Hexi District, Tianjin, 300074, China., Wang X; Clinical School of Paediatrics, Tianjin Medical University, Tianjin, China.; Department of Pulmonology, Tianjin Children's Hospital (Children's Hospital of Tianjin University), Machang Compus, 225 Machang Road, Hexi District, Tianjin, 300074, China., Yun YN; Department of Pulmonology, Tianjin Children's Hospital (Children's Hospital of Tianjin University), Machang Compus, 225 Machang Road, Hexi District, Tianjin, 300074, China., Wang XL; Department of Pulmonology, Tianjin Children's Hospital (Children's Hospital of Tianjin University), Machang Compus, 225 Machang Road, Hexi District, Tianjin, 300074, China., He EY; Clinical School of Paediatrics, Tianjin Medical University, Tianjin, China., Song MK; Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin, 300070, China., Xia XH; Clinical School of Paediatrics, Tianjin Medical University, Tianjin, China., Zou YX; Department of Pulmonology, Tianjin Children's Hospital (Children's Hospital of Tianjin University), Machang Compus, 225 Machang Road, Hexi District, Tianjin, 300074, China. tmuzouyingxue@163.com.
Jazyk: angličtina
Zdroj: International archives of occupational and environmental health [Int Arch Occup Environ Health] 2024 Apr; Vol. 97 (3), pp. 331-339. Date of Electronic Publication: 2024 Feb 27.
DOI: 10.1007/s00420-024-02047-1
Abstrakt: Background: Previous epidemiological studies about the relationship between per- and polyfluoroalkyl substances (PFAS) concentrations and adolescent asthma have typically examined single PFAS, without considering the mixtures effects of PFAS.
Methods: Using data from the 2013-2018 National Health and Nutrition Examination Survey (NHANES), 886 adolescents aged 12-19 years were included in this study. We explored the association between PFAS mixture concentrations and adolescent asthma using weighted quantile sum (WQS) regression and Bayesian kernel machine regression (BKMR) models, respectively.
Results: After adjusting for confounders, the results of the WQS regression and BKMR models were consistent, with mixed exposure to the five PFAS not significantly associated with asthma in all adolescents. The association remained nonsignificant in the subgroup analysis by sex.
Conclusions: Our study demonstrated no significant association between mixed exposure to PFAS and adolescent asthma, and more large cohort studies are needed to confirm this in the future.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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