ITAM-based receptors in natural killer cells.

Autor: Aguilar OA; Department of Microbiology and Immunology, University of California - San Francisco, San Francisco, California, USA.; Parker Institute for Cancer Immunotherapy, University of California - San Francisco, San Francisco, California, USA., Fong LK; Department of Pharmaceutical Chemistry, University of California - San Francisco, San Francisco, California, USA., Lanier LL; Department of Microbiology and Immunology, University of California - San Francisco, San Francisco, California, USA.; Parker Institute for Cancer Immunotherapy, University of California - San Francisco, San Francisco, California, USA.
Jazyk: angličtina
Zdroj: Immunological reviews [Immunol Rev] 2024 May; Vol. 323 (1), pp. 40-53. Date of Electronic Publication: 2024 Feb 27.
DOI: 10.1111/imr.13313
Abstrakt: The ability of cells of the immune system to acquire features such as increased longevity and enhanced secondary responses was long thought to be restricted to cells of the adaptive immune system. Natural killer (NK) cells have challenged this notion by demonstrating that they can also gain adaptive features. This has been observed in both humans and mice during infection with cytomegalovirus (CMV). The generation of adaptive NK cells requires antigen-specific recognition of virally infected cells through stimulatory NK receptors. These receptors lack the ability to signal on their own and rather rely on adaptor molecules that contain ITAMs for driving signals. Here, we highlight our understanding of how these receptors influence the production of adaptive NK cells and propose areas in the field that merit further investigation.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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