Effectiveness of perindopril/amlodipine fixed-dose combination in the treatment of hypertension: a systematic review.

Autor:	Dat TV; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Tu VL; Faculty of Traditional Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Thu LNA; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Quang NNA; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Binh V; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Nga NTQ; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Loc DH; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Nguyen TTH; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Tam DNH; Regulatory Affairs Department, Asia Shine Trading & Service Co. LTD., Ho Chi Minh City, Vietnam., Huynh HH; International Master Program for Translational Science, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan., Trung TD; Faculty of Public Health, Danang University of Medical Technology and Pharmacy, Danang, Vietnam., Do U; Nelda C. Stark School of Nursing, Texas Woman’s University, Houston, TX, United States., Phat NT; Cardiovascular Research Department, Methodist Hospital, Merrillville, IN, United States., Hung DT; School of Biomedical Engineering & Imaging Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, United Kingdom., Nguyen QH; Cardiovascular Research Department, Methodist Hospital, Merrillville, IN, United States., Yen NTH; Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam., Minh LHN; International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Research Center for Artificial Intelligence in Medicine, Taipei Medical University, Taipei, Taiwan
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2024 Feb 08; Vol. 14, pp. 1156655. Date of Electronic Publication: 2024 Feb 08 (Print Publication: 2023).
DOI:	10.3389/fphar.2023.1156655
Abstrakt:	Background: Uncontrolled blood pressure is a major risk factor for cardiovascular diseases. Fixed-dose combination (FDC) therapy offers a promising approach to addressing this challenge by providing a convenient single-tablet solution that enhances the effectiveness of blood pressure control. In our systematic review, we assess the effectiveness of perindopril/amlodipine FDC in managing blood pressure. Methods: We conducted a comprehensive search across four primary electronic databases, namely, PubMed, Virtual Health Library (VHL), Global Health Library (GHL), and Google Scholar, as of 8 February 2022. Additionally, we performed a manual search to find relevant articles. The quality of the selected articles was evaluated using the Study Quality Assessment Tools (SQAT) checklist from the National Institute of Health and the ROB2 tool from Cochrane. Results: Our systematic review included 17 eligible articles. The findings show that the use of perindopril/amlodipine FDC significantly lowers blood pressure and enhances the quality of blood pressure control. Compared to the comparison group, the perindopril/amlodipine combination tablet resulted in a higher rate of blood pressure response and normalization. Importantly, perindopril/amlodipine FDC contributes to improved patient adherence with minimal side effects. However, studies conducted to date have not provided assessments of the cost-effectiveness of perindopril/amlodipine FDC. Conclusion: In summary, our analysis confirms the effectiveness of perindopril/amlodipine FDC in lowering blood pressure, with combination therapy outperforming monotherapy and placebo. Although mild adverse reactions were observed in a small subset of participants, cost-effectiveness assessments for this treatment remain lacking in the literature. Competing Interests: Author DT was employed by Asia Shine Trading & Service Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Dat, Tu, Thu, Quang, Binh, Nga, Loc, Nguyen, Tam, Huynh, Trung, Do, Phat, Hung, Nguyen, Yen and Minh.)
Databáze:	MEDLINE
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