The human factor H protein family - an update.

Autor:	Sándor N; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.; HUN-REN-ELTE Complement Research Group, Hungarian Research Network, Budapest, Hungary., Schneider AE; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary., Matola AT; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary., Barbai VH; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary., Bencze D; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary., Hammad HH; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary., Papp A; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary., Kövesdi D; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.; HUN-REN-ELTE Complement Research Group, Hungarian Research Network, Budapest, Hungary., Uzonyi B; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.; HUN-REN-ELTE Complement Research Group, Hungarian Research Network, Budapest, Hungary., Józsi M; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.; HUN-REN-ELTE Complement Research Group, Hungarian Research Network, Budapest, Hungary.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2024 Feb 12; Vol. 15, pp. 1135490. Date of Electronic Publication: 2024 Feb 12 (Print Publication: 2024).
DOI:	10.3389/fimmu.2024.1135490
Abstrakt:	Complement is an ancient and complex network of the immune system and, as such, it plays vital physiological roles, but it is also involved in numerous pathological processes. The proper regulation of the complement system is important to allow its sufficient and targeted activity without deleterious side-effects. Factor H is a major complement regulator, and together with its splice variant factor H-like protein 1 and the five human factor H-related (FHR) proteins, they have been linked to various diseases. The role of factor H in inhibiting complement activation is well studied, but the function of the FHRs is less characterized. Current evidence supports the main role of the FHRs as enhancers of complement activation and opsonization, i.e., counter-balancing the inhibitory effect of factor H. FHRs emerge as soluble pattern recognition molecules and positive regulators of the complement system. In addition, factor H and some of the FHR proteins were shown to modulate the activity of immune cells, a non-canonical function outside the complement cascade. Recent efforts have intensified to study factor H and the FHRs and develop new tools for the distinction, quantification and functional characterization of members of this protein family. Here, we provide an update and overview on the versatile roles of factor H family proteins, what we know about their biological functions in healthy conditions and in diseases. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Sándor, Schneider, Matola, Barbai, Bencze, Hammad, Papp, Kövesdi, Uzonyi and Józsi.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu