Presurgical Pulmonary Function Tests in the First Few Days of Life in Neonates with Congenital Heart Disease, A Pilot Study.

Autor:	McEvoy C; Oregon Health & Science University., Leeds H, Muralidaran A, Johnson A, Schilling D, Parkhotyuk K, Shen I
Jazyk:	angličtina
Zdroj:	Research square [Res Sq] 2024 Feb 13. Date of Electronic Publication: 2024 Feb 13.
DOI:	10.21203/rs.3.rs-3938413/v1
Abstrakt:	Objective: To compare early pulmonary function tests (PFTs) in neonates with critical congenital heart disease (CHD) compared to a historical reference group. Design: Infants > 37 weeks gestation with critical CHD were studied within the first few days of life and prior to cardiac surgery and compared to data from a published reference group. Passive respiratory resistance (Rrs) and compliance (Crs) were measured with the single breath occlusion technique following specific acceptance criteria. The study was powered for a 30% difference in Rrs. Results: PFTs in 24 infants with CHD were compared to 31 historical reference infants. There was no difference in the Rrs between the groups. The infants with CHD had a significantly decreased Crs (1.02 ± 0.26 mL/cmH2O/kg versus 1.32 ± 0.36; (p < 0.05; mean ± SD)). Conclusions: Further prospective studies are required to quantify early PFTs in infants with CHD of different phenotypes. Competing Interests: The authors have no conflicts of interest to disclose. The study sponsors had no role in any of the following: 1) study design; 2) the collection, analysis, and interpretation of data; 3) the writing of the report; or 4) the decision to submit the manuscript for publication.
Databáze:	MEDLINE
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