Emerging Horizons in the Diagnosis of Pancreatic Cancer: The Role of Circulating microRNAs as Early Detection Biomarkers for Pancreatic Ductal Adenocarcinoma.

Autor:	Reyaz I; Internal Medicine, Christian Medical College and Hospital Ludhiana, Ludhiana, IND., Khan B; Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK., James N; General Medicine, Rehman Medical Institute, Peshawar, PAK., Azhar H; Accident and Emergency, Sahiwal Teaching Hospital, Sahiwal, PAK.; General Medicine, King Edward Medical University, Lahore, PAK., Rehman A; Surgery, Mayo Hospital, Lahore, PAK., Younas MW; Accident and Emergency, Sahiwal Teaching Hospital, Sahiwal, PAK.; General Medicine, Faisalabad Medical University, Faisalabad, PAK., Rashid H; Medicine, Pak Medical Centre & Hospital, Peshawar, PAK., Al-Shaikhly FF; Medicine and Surgery, University of Jordan, Amman, JOR., Almomani MM; Medicine and Surgery, The University of Jordan, Amman, JOR., I Kh Almadhoun MK; Medicine and Surgery, Mutah University, Karak, JOR., Abdullah Yahya N; Department of Medicine, Dubai Medical College, Dubai, ARE., Bokhari SFH; Surgery, King Edward Medical University, Lahore, PAK., Shehzad A; Surgery, King Edward Medical University, Lahore, PAK.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jan 26; Vol. 16 (1), pp. e53023. Date of Electronic Publication: 2024 Jan 26 (Print Publication: 2024).
DOI:	10.7759/cureus.53023
Abstrakt:	Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a poor prognosis, primarily due to a late diagnosis. Recent studies have focused on identifying non-invasive biomarkers for early detection, with microRNAs (miRNAs) emerging as promising candidates. This systematic review aims to evaluate the potential of circulating miRNAs as biomarkers for the early detection of PDAC, analyzing their diagnostic accuracy, specificity, and sensitivity. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive search across PubMed, Embase, and the Cochrane Library was conducted. Studies published from January 2013 to October 2023 focusing on miRNA biomarkers for early PDAC detection were included. Data synthesis was performed through a narrative approach due to the heterogeneity of the studies. Nine studies met the inclusion criteria. Key findings include the elevated levels of specific miRNAs, such as miR-18a, miR-106a, and miR-25, in early-stage PDAC patients compared to controls. The integration of miRNA profiles with traditional biomarkers like CA19-9 showed improved diagnostic performance. However, challenges in the standardization of miRNA evaluation methodologies were noted. Circulating miRNAs demonstrate significant potential as non-invasive biomarkers for early PDAC detection. Despite promising results, further research and standardization are necessary for clinical application. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Reyaz et al.)
Databáze:	MEDLINE
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