Abdominal fat depots are related to lower cognitive functioning and brain volumes in middle-aged males at high Alzheimer's risk.

Autor: Golan Shekhtman S; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel., Boccara E; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel.; Department of Psychology, Bar Ilan University, Ramat Gan, Israel., Ravona-Springer R; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel.; Memory Clinic, Sheba Medical Center, Tel HaShomer, Israel., Inbar Y; Department of Diagnostic Imaging, Sheba Medical Center, Tel HaShomer, Israel., Zelicha H; The Health & Nutrition Innovative International Research Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel., Livny A; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel.; Department of Diagnostic Imaging, Sheba Medical Center, Tel HaShomer, Israel.; The Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Bendlin BB; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Lesman-Segev O; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel.; Department of Diagnostic Imaging, Sheba Medical Center, Tel HaShomer, Israel., Yore I; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel., Heymann A; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Sano M; Geriatric Research Education and Clinical Center, James J. Peters VA Medical Center, Bronx, New York, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Mardor Y; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Diagnostic Imaging, Sheba Medical Center, Tel HaShomer, Israel., Azuri J; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Maccabi Healthcare Services, Tel Aviv, Israel., Schnaider Beeri M; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Jazyk: angličtina
Zdroj: Obesity (Silver Spring, Md.) [Obesity (Silver Spring)] 2024 May; Vol. 32 (5), pp. 1009-1022. Date of Electronic Publication: 2024 Feb 27.
DOI: 10.1002/oby.24004
Abstrakt: Objective: High BMI, which poorly represents specific fat depots, is linked to poorer cognition and higher dementia risk, with different associations between sexes. This study examined associations of abdominal fat depots with cognition and brain volumes and whether sex modifies this association.
Methods: A total of 204 healthy middle-aged offspring of Alzheimer's dementia patients (mean age = 59.44, 60% females) underwent abdominal magnetic resonance imaging to quantify hepatic, pancreatic, visceral, and subcutaneous adipose tissue and to assess cognition and brain volumes.
Results: In the whole sample, higher hepatic fat percentage was associated with lower total gray matter volume (β = -0.17, p < 0.01). Primarily in males, higher pancreatic fat percentage was associated with lower global cognition (males: β = -0.27, p = 0.03; females: β = 0.01, p = 0.93) executive function (males: β = -0.27, p = 0.03; females: β = 0.02, p = 0.87), episodic memory (males: β = -0.28, p = 0.03; females: β = 0.07, p = 0.48), and inferior frontal gyrus volume (males: β = -0.28, p = 0.02; females: β = 0.10, p = 0.33). Visceral and subcutaneous adipose tissue was inversely associated with middle frontal and superior frontal gyrus volumes in males and females.
Conclusions: In middle-aged males at high Alzheimer's dementia risk, but not in females, higher pancreatic fat was associated with lower cognition and brain volumes. These findings suggest a potential sex-specific link between distinct abdominal fat with brain health.
(© 2024 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society.)
Databáze: MEDLINE
Externí odkaz: