A diffusible small-RNA-based Turing system dynamically coordinates organ polarity.

Autor: Scacchi E; Center for Plant Molecular Biology, University of Tübingen, Tübingen, Germany. emanuele.scacchi@zmbp.uni-tuebingen.de., Paszkiewicz G; Center for Plant Molecular Biology, University of Tübingen, Tübingen, Germany., Thi Nguyen K; Center for Plant Molecular Biology, University of Tübingen, Tübingen, Germany.; NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam., Meda S; Center for Plant Molecular Biology, University of Tübingen, Tübingen, Germany., Burian A; Institute of Biology, Biotechnology and Environmental Protection, University of Silesia in Katowice, Katowice, Poland., de Back W; Institute for Medical Informatics and Biometry, Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany., Timmermans MCP; Center for Plant Molecular Biology, University of Tübingen, Tübingen, Germany. marja.timmermans@zmbp.uni-tuebingen.de.
Jazyk: angličtina
Zdroj: Nature plants [Nat Plants] 2024 Mar; Vol. 10 (3), pp. 412-422. Date of Electronic Publication: 2024 Feb 26.
DOI: 10.1038/s41477-024-01634-x
Abstrakt: The formation of a flat and thin leaf presents a developmentally challenging problem, requiring intricate regulation of adaxial-abaxial (top-bottom) polarity. The patterning principles controlling the spatial arrangement of these domains during organ growth have remained unclear. Here we show that this regulation in Arabidopsis thaliana is achieved by an organ-autonomous Turing reaction-diffusion system centred on mobile small RNAs. The data illustrate how Turing dynamics transiently instructed by prepatterned information is sufficient to self-sustain properly oriented polarity in a dynamic, growing organ, presenting intriguing parallels to left-right patterning in the vertebrate embryo. Computational modelling demonstrates that this self-organizing system continuously adapts to coordinate the robust planar polarity of a flat leaf while affording flexibility to generate the tissue patterns of evolutionarily diverse organ shapes. Our findings identify a small-RNA-based Turing network as a dynamic regulator of organ polarity that accounts for leaf shape diversity at the level of the individual organ, plant or species.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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