Prenatal exposure to polybrominated diphenyl ether (PBDE) and child neurodevelopment: The role of breastfeeding duration.

Autor: Wallenborn JT; Center of Excellence for Maternal and Child Health, School of Public Health, University of California, Berkeley, CA, USA; Swiss Tropical and Public Health Institute, Department of Epidemiology and Public Health, Basel, Switzerland; University of Basel, Basel, Switzerland. Electronic address: jordyn.wallenborn@swisstph.ch., Hyland C; Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA; Division of Agriculture and Natural Resources, University of California, Berkeley, CA, USA; Center for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA., Sagiv SK; Center for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA., Kogut KR; Center for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA., Bradman A; Department of Public Health, School of Social Sciences, Humanities, and Arts, University of California, Merced, USA., Eskenazi B; Center for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2024 Apr 15; Vol. 921, pp. 171202. Date of Electronic Publication: 2024 Feb 24.
DOI: 10.1016/j.scitotenv.2024.171202
Abstrakt: Background: Prenatal and early-life exposure to polybrominated diphenyl ethers (PBDEs) is associated with detrimental and irreversible neurodevelopmental health outcomes during childhood. Breastfeeding may be a child's largest sustained exposure to PBDE- potentially exacerbating their risk for adverse neurodevelopment outcomes. However, breastfeeding has also been associated with positive neurodevelopment. Our study investigates if breastfeeding mitigates or exacerbates the known adverse effects of prenatal exposure to PBDEs and child neurodevelopment.
Methods: Participants included 321 mother-infant dyads from the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS), a longitudinal birth cohort in California. PBDE concentrations were measured in maternal serum blood samples collected during pregnancy or at delivery. Using generalized estimated equations (GEE), we estimated associations of PBDE concentrations with children's attention, executive function, and cognitive scores assessed longitudinally between 7 and 12 years of age, stratified by duration of exclusive and complementary breastfeeding.
Results: We observed that higher maternal prenatal PBDE concentrations were associated with poorer executive function among children who were complementary breastfed for a shorter duration compared to children breastfed for a longer duration; preservative errors (β for 10-fold increase in complementary breastfeeding <7 months = -6.6; 95 % Confidence Interval (CI): -11.4, -1.8; β ≥ 7 months = -5.1; 95 % CI: -10.2, 0.1) and global executive composition (β for 10-fold increase <7 months = 4.3; 95 % CI: 0.4, 8.2; β for 10-fold increase ≥7 months = 0.6; 95 % CI: -2.8, 3.9).
Conclusions: Prolonged breastfeeding does not exacerbate but may mitigate some previously observed negative associations of prenatal PBDE exposure and child neurodevelopment.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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