Ameliorative effects of thymoquinone on the caspase 3, kidney function and oxidative stress tartrazine-induced nephrotoxicity.

Autor: Erdemli Z; Department of Medical Biochemistry, Medical Faculty, Inonu University, Malatya, Turkey., Gul M; Department of Histology and Embryology, Medical Faculty, Inonu University, Malatya, Turkey., Gokturk N; Department of Medical Biochemistry, Medical Faculty, Inonu University, Malatya, Turkey., Kayhan E; Department of Histology and Embryology, Medical Faculty, Turgut Ozal University, Malatya, Turkey., Demircigil N; Department of Medical Biochemistry, Medical Faculty, Inonu University, Malatya, Turkey., Ozsoy EN; Department of Histology and Embryology, Medical Faculty, Inonu University, Malatya, Turkey., Gozukara Bag H; Department of Biostatistics, Medical Faculty, Inonu University, Malatya, Turkey., Erdemli ME; Department of Medical Biochemistry, Medical Faculty, Inonu University, Malatya, Turkey. Electronic address: ermanerdemli@inonu.edu.tr.
Jazyk: angličtina
Zdroj: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2024 Apr; Vol. 241, pp. 107660. Date of Electronic Publication: 2024 Feb 24.
DOI: 10.1016/j.toxicon.2024.107660
Abstrakt: First in the literature this study aimed to investigate the effects of Tartrazine, a common industrial food dye, on kidney and whether Thymoquinone has a protective effect in tartrazine-induced nephrotoxicity. The study conducted on the rats bred at İnönü University Experimental Animals Production and Research Center. Wistar albino rats were randomly divided into 4 groups, where each group included 8 rats: control, Tartrazine, Thymoquinone, and Tartrazine + Thymoquinone groups. The experiments continued for 3 weeks and then, kidney tissues and blood samples were collected from the rats under anesthesia. Malondialdehyde (MDA), super oxidized dismutase (SOD), total oxidant status (TOS), increase in Oxidative stress index (OSI), glutathione (GSH), Glutathione peroxidase (GSH-Px), catalase (CAT), Total antioxidant status (TAS) levels decreased in the kidney tissues collected from the tartrazine group. Serum Bun and Creatinine levels increased in the tartrazine group. Tartrazine administration damaged and degenerated the glomeruli and cortical distal tubes in the histopathology of kidney tissues, also different degrees of inflammatory cell infiltration were observed in the renal cortex and medulla. Thymoquinone and tartrazine administration improved both biochemical and histopathological parameters. Tartrazine administration induced nephrotoxicity. This could be observed with the increase in oxidant capacity and the deterioration of kidney functions. Thymoquinone was observed to demonstrate strong antioxidant properties. Thymoquinone could be used primarily as a protective agent against Tartrazine-induced toxicity.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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