Safety, tolerability and blinding efficiency of non-invasive deep transcranial temporal interference stimulation: first experience from more than 250 sessions.

Autor:	Vassiliadis P; Defitech Chair of Clinical Neuroengineering, Neuro-X Institute (INX), École Polytechnique Fédérale de Lausanne (EPFL), 1202 Geneva, Switzerland.; Defitech Chair of Clinical Neuroengineering, INX, EPFL Valais, Clinique Romande de Réadaptation, 1951 Sion, Switzerland., Stiennon E; Louvain School of Engineering, Université Catholique de Louvain, Louvain-la-Neuve, Belgium., Windel F; Defitech Chair of Clinical Neuroengineering, Neuro-X Institute (INX), École Polytechnique Fédérale de Lausanne (EPFL), 1202 Geneva, Switzerland.; Defitech Chair of Clinical Neuroengineering, INX, EPFL Valais, Clinique Romande de Réadaptation, 1951 Sion, Switzerland., Wessel MJ; Department of Neurology, University Hospital Würzburg, Würzburg, Germany., Beanato E; Defitech Chair of Clinical Neuroengineering, Neuro-X Institute (INX), École Polytechnique Fédérale de Lausanne (EPFL), 1202 Geneva, Switzerland.; Defitech Chair of Clinical Neuroengineering, INX, EPFL Valais, Clinique Romande de Réadaptation, 1951 Sion, Switzerland., Hummel FC; Defitech Chair of Clinical Neuroengineering, Neuro-X Institute (INX), École Polytechnique Fédérale de Lausanne (EPFL), 1202 Geneva, Switzerland.; Defitech Chair of Clinical Neuroengineering, INX, EPFL Valais, Clinique Romande de Réadaptation, 1951 Sion, Switzerland.; Clinical Neuroscience, University of Geneva Medical School, 1202 Geneva, Switzerland.
Jazyk:	angličtina
Zdroj:	Journal of neural engineering [J Neural Eng] 2024 Mar 11; Vol. 21 (2). Date of Electronic Publication: 2024 Mar 11.
DOI:	10.1088/1741-2552/ad2d32
Abstrakt:	Objective . Selective neuromodulation of deep brain regions has for a long time only been possible through invasive approaches, because of the steep depth-focality trade-off of conventional non-invasive brain stimulation (NIBS) techniques. Approach . An approach that has recently emerged for deep NIBS in humans is transcranial Temporal Interference Stimulation (tTIS). However, a crucial aspect for its potential wide use is to ensure that it is tolerable, compatible with efficient blinding and safe. Main results . Here, we show the favorable tolerability and safety profiles and the robust blinding efficiency of deep tTIS targeting the striatum or hippocampus by leveraging a large dataset (119 participants, 257 sessions), including young and older adults and patients with traumatic brain injury. tTIS-evoked sensations were generally rated as 'mild', were equivalent in active and placebo tTIS conditions and did not enable participants to discern stimulation type. Significance . Overall, tTIS emerges as a promising tool for deep NIBS for robust double-blind, placebo-controlled designs. (Creative Commons Attribution license.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu