Investigation of occupational risk factors for the development of non-Hodgkin's lymphoma in adults: A hospital-based case-control study.

Autor: Sarpa M; Coordination of Prevention and Surveillance, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.; Environmental Mutagenesis Laboratory, Federal University of Rio de Janeiro State (UNIRIO), Rio de Janeiro, Brazil., da Costa VÍDB; Coordination of Prevention and Surveillance, Brazilian National Cancer Institute, Rio de Janeiro, Brazil., Ferreira SN; Coordination of Prevention and Surveillance, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.; Environmental Mutagenesis Laboratory, Federal University of Rio de Janeiro State (UNIRIO), Rio de Janeiro, Brazil., de Almeida CÁ; Coordination of Prevention and Surveillance, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.; Environmental Mutagenesis Laboratory, Federal University of Rio de Janeiro State (UNIRIO), Rio de Janeiro, Brazil., de Oliveira PGS; Coordination of Prevention and Surveillance, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.; Environmental Mutagenesis Laboratory, Federal University of Rio de Janeiro State (UNIRIO), Rio de Janeiro, Brazil., de Mesquita LV; Coordination of Prevention and Surveillance, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.; Environmental Mutagenesis Laboratory, Federal University of Rio de Janeiro State (UNIRIO), Rio de Janeiro, Brazil., Schilithz AOC; Coordination of Prevention and Surveillance, Brazilian National Cancer Institute, Rio de Janeiro, Brazil., Stefanoff CG; Coordination of Clinical Research and Technological Incorporation, Brazilian National Cancer Institute, Rio de Janeiro, RJ, Brazil., Hassan R; Oncovirology Laboratory, Bone Marrow Transplantation Center, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil., Otero UB; Coordination of Prevention and Surveillance, Brazilian National Cancer Institute, Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Feb 26; Vol. 19 (2), pp. e0297140. Date of Electronic Publication: 2024 Feb 26 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0297140
Abstrakt: Non-Hodgkin's Lymphoma (NHL) is a malignancy of the lymphoid lineage of the hematopoietic system has worldwide, especially in developed countries. Better diagnostic and recording techniques, longer life expectancy, and greater exposure to risk factors are hypotheses for this growing incidence curve. Occupational exposures to chemical, biological, and physical agents have also been associated with NHL development, but the results are still controversial. We have investigated the occupational and lifestyle case-control study design with 214 adult patients and 452 population controls. Socio-demographic, clinical, and occupational exposure data were obtained through individual interviews with a standardized questionnaire. Clinical, laboratory, and histopathological data were obtained through medical records. Risk of NHL (any subtype), B-cell lymphoma, DLBCL, Follicular lymphoma and T-cell lymphoma was elevated among the those who had ever been exposed to any solvents, hydrocarbon solvents, pesticides, meat and meat products, and sunlight and tended to increase by years of exposure. A significant upward trend with years of exposure was detected for any solvents and hydrocarbon solvents (NHL (any subtype) p-value for trend<0.001), B-cell lymphoma (p-value for trend<0.001), and T-cell lymphoma (p-value for trend<0.023), pesticides (NHL (any subtype), p for trend<0.001) and T-cell lymphoma (p for trend<0.002), meat and meat products (NHL (any subtype) (p for trend<0.001) and DLBCL (p for trend<0.001), and sunlight (B-cell lymphoma (p for trend<0.001). The results of this study agree line with other international studies, can be extrapolated to other countries that have the same socio-demographic and occupational characteristics as Brazil and support strategies for surveillance and control of work-related cancer.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Sarpa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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