Long-term lymphocyte subset number reconstitution is unique but comparable between umbilical cord blood and unrelated bone marrow transplantation.

Autor: Tsumita K; Department of Clinical Laboratory, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 1050001, Japan., Takagi S; Department of Hematology, Toranomon Hospital, Tokyo, Japan.; Center for Long-Term Follow-Up After Hematopoietic Cell Transplantation, Toranomon Hospital, Tokyo, Japan.; Okinaka Memorial Institute for Medical Research, Tokyo, Japan., Asano-Mori Y; Department of Hematology, Toranomon Hospital, Tokyo, Japan.; Center for Long-Term Follow-Up After Hematopoietic Cell Transplantation, Toranomon Hospital, Tokyo, Japan.; Department of Transfusion Medicine, Toranomon Hospital, Tokyo, Japan., Watanabe O; Department of Hematology, Toranomon Hospital, Tokyo, Japan., Shindo M; Department of Hematology, Toranomon Hospital, Tokyo, Japan., Yamaguchi K; Department of Hematology, Toranomon Hospital Kajigaya, Kawasaki, Japan., Yuasa M; Department of Hematology, Toranomon Hospital, Tokyo, Japan., Kageyama K; Department of Hematology, Toranomon Hospital Kajigaya, Kawasaki, Japan., Kaji D; Department of Hematology, Toranomon Hospital, Tokyo, Japan.; Department of Transfusion Medicine, Toranomon Hospital, Tokyo, Japan., Taya Y; Department of Hematology, Toranomon Hospital, Tokyo, Japan.; Department of Transfusion Medicine, Toranomon Hospital, Tokyo, Japan., Nishida A; Department of Hematology, Toranomon Hospital, Tokyo, Japan., Ishiwata K; Department of Hematology, Toranomon Hospital Kajigaya, Kawasaki, Japan., Yamamoto H; Department of Hematology, Toranomon Hospital, Tokyo, Japan.; Center for Long-Term Follow-Up After Hematopoietic Cell Transplantation, Toranomon Hospital, Tokyo, Japan., Araoka H; Department of Infectious Diseases, Toranomon Hospital, Tokyo, Japan., Yamamoto G; Department of Hematology, Toranomon Hospital, Tokyo, Japan., Makino S; Japanese Red Cross Tokyo Metropolitan Blood Center, Tokyo, Japan., Wake A; Center for Long-Term Follow-Up After Hematopoietic Cell Transplantation, Toranomon Hospital, Tokyo, Japan.; Department of Hematology, Toranomon Hospital Kajigaya, Kawasaki, Japan., Uchida N; Department of Hematology, Toranomon Hospital, Tokyo, Japan.; Okinaka Memorial Institute for Medical Research, Tokyo, Japan., Taniguchi S; Department of Hematology, Toranomon Hospital, Tokyo, Japan., Koike Y; Department of Clinical Laboratory, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 1050001, Japan. yukako-tky@umin.ac.jp.
Jazyk: angličtina
Zdroj: International journal of hematology [Int J Hematol] 2024 May; Vol. 119 (5), pp. 573-582. Date of Electronic Publication: 2024 Feb 26.
DOI: 10.1007/s12185-024-03727-x
Abstrakt: The number of umbilical cord blood transplantation (U-CBT) procedures has been growing annually, but little research has been done on long-term immune recovery after U-CBT. Infection risk is high in U-CBT recipients, and this can be partially attributed to immature immunocompetent cells in umbilical cord blood. In this study, we analyzed lymphocyte subset (LST) number to determine the long-term recovery timeline. We included 36 U-CBT and 10 unrelated bone marrow transplantation (U-BMT) recipients who survived more than 2 years after transplantation, and followed them for up to 10 years post-transplant. Recovery kinetics in the early phase post-transplant was different for each LST. Recovery of CD19 + B cells was faster after U-CBT than after U-BMT in the first 5 years after transplantation. Although CD4 + T cells increased in the first several months after U-CBT, long-term cell count recovery was impaired in approximately 20% of patients. Thus, although the LST recovery pattern after U-CBT was unique, LST number recovery was statistically comparable between U-CBT and U-BMT past 5 years post-transplantation.
(© 2024. Japanese Society of Hematology.)
Databáze: MEDLINE
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