REDISCOVER International Guidelines on the Perioperative Care of Surgical Patients With Borderline-resectable and Locally Advanced Pancreatic Cancer.

Autor:	Boggi U; Division of General and Transplant Surgery, University of Pisa, Pisa, Italy., Kauffmann E; Division of General and Transplant Surgery, University of Pisa, Pisa, Italy., Napoli N; Division of General and Transplant Surgery, University of Pisa, Pisa, Italy., Barreto SG; College of Medicine and Public Health, Flinders University, Bedford Park, SA, Australia.; Division of Surgery and Perioperative Medicine, Flinders Medical Center, Bedford Park, SA, Australia., Besselink MG; Department of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Amsterdam, The Netherlands., Fusai GK; HPB & Liver Transplant Unit, Royal Free Hospital, London, UK., Hackert T; Department of General, Visceral and Thoracic Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Abu Hilal M; Department of Surgery, Poliambulanza Foundation Hospital, Brescia, Italy., Marchegiani G; Hepatopancreatobiliary and Liver Transplant Surgery, Department of Surgery, Oncology and Gastroenterology, DiSCOG, University of Padua, Padua, Italy., Salvia R; General and Pancreatic Surgery Unit, Pancreas Institute, University of Verona, Verona, Italy., Shrikhande SV; Tata Memorial Hospital, Gastrointestinal and HPB Service, Homi Bhabha National Institute, Tata Memorial Centre, Mumbai, Maharashtra, India., Truty M; Department of Surgery, Division of Hepatobiliary & Pancreas Surgery, Mayo Clinic Rochester, Rochester, MN., Werner J; Department of General, Visceral, and Transplant Surgery, LMU, University of Munich, Munich, Germany., Wolfgang CL; Department of Surgery, The NYU Grossman School of Medicine and NYU Langone Health, New York, NY., Bannone E; Department of Surgery, Poliambulanza Foundation Hospital, Brescia, Italy., Capretti G; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.; Associazione Oncologica Pisana P. Trivella, Pisa, Italy., Cattelani A; General and Pancreatic Surgery Unit, Pancreas Institute, University of Verona, Verona, Italy., Coppola A; Department of Surgery, Sapienza University of Rome, Rome, Italy., Cucchetti A; Department of Medical and Surgical Sciences-DIMEC, Alma Mater Studiorum Università di Bologna, Bologna, Italy., De Sio D; Gemelli Pancreatic Center, CRMPG (Advanced Pancreatic Research Center), Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, UNIVERSITA' CATTOLICA DEL SACRO CUORE, Rome, Italy., Di Dato A; Division of General and Transplant Surgery, University of Pisa, Pisa, Italy., Di Meo G; Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari, Bari, Italy., Fiorillo C; Gemelli Pancreatic Center, CRMPG (Advanced Pancreatic Research Center), Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, UNIVERSITA' CATTOLICA DEL SACRO CUORE, Rome, Italy., Gianfaldoni C; Division of General and Transplant Surgery, University of Pisa, Pisa, Italy., Ginesini M; Division of General and Transplant Surgery, University of Pisa, Pisa, Italy., Hidalgo Salinas C; Kellogg College, University of Oxford, Oxford, UK., Lai Q; Department of General and Specialty Surgery, Sapienza University of Rome, AOU Policlinico Umberto I of Rome, Rome, Italy., Miccoli M; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Montorsi R; Department of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Amsterdam, The Netherlands., Pagnanelli M; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.; Associazione Oncologica Pisana P. Trivella, Pisa, Italy., Poli A; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Ricci C; Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna, Italy.; Division of Pancreatic Surgery, IRCCS, Azienda Ospedaliero-Universitaria di Bologna (IRCCS AOUBO), Bologna, Italy., Sucameli F; Department of Surgery, Poliambulanza Foundation Hospital, Brescia, Italy., Tamburrino D; Division of Pancreatic Surgery, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy., Viti V; Division of General and Transplant Surgery, University of Pisa, Pisa, Italy., Addeo PF; Division of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Hôpital de Hautepierre-Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France., Alfieri S; Gemelli Pancreatic Center, CRMPG (Advanced Pancreatic Research Center), Fondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, UNIVERSITA' CATTOLICA DEL SACRO CUORE, Rome, Italy., Bachellier P; Division of Hepato-Pancreato-Biliary Surgery and Liver Transplantation, Hôpital de Hautepierre-Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France., Baiocchi GL; Department of Clinical and Experimental Sciences, University of Brescia and UOC General Surgery, ASST Cremona, Cremona, Italy., Balzano G; Division of Pancreatic Surgery, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy., Barbarello L; Division of General and Transplant Surgery, University of Pisa, Pisa, Italy., Brolese A; Department of General Surgery & HPB Unit, APSS, Trento, Italy., Busquets J; Division of Pancreatobiliary Surgery and Liver Transplantation, Department of Surgery, Bellvitge University Hospital, IDIBELL, L´Hospitalet de Llobregat, Barcelona, Spain., Butturini G; Hepatopancreatobiliary Surgery, Pederzoli Hospital, Peschiera del Garda, Verona, Italy., Caniglia F; Division of General and Transplant Surgery, University of Pisa, Pisa, Italy., Caputo D; Research Unit of General Surgery, Department of Medicine and Surgery, University Campus Bio-Medico di Roma, Rome, Italy.; Operative Research Unit of General Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy., Casadei R; Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna, Italy.; Division of Pancreatic Surgery, IRCCS, Azienda Ospedaliero-Universitaria di Bologna (IRCCS AOUBO), Bologna, Italy., Chunhua X; Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.; Pancreas Institute, Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China., Colangelo E; Department of General Surgery, 'G. Mazzini' Hospital, Teramo, Italy., Coratti A; Department of General and Emergency Surgery, AUSL Toscana Sud Est, Misericordia Hospital of Grosseto, Grosseto, Italy., Costa F; Division of General and Transplant Surgery, University of Pisa, Pisa, Italy., Crafa F; Division of General, Oncological and Robotic Surgery, San Giuseppe Moscati Hospital, Avellino, Italy., Dalla Valle R; Department of Medicine and Surgery, HPB Unit, University of Parma, Parma, Italy., De Carlis L; Division of HPB Surgery and Transplantation, Niguarda Hospital, University of Milano-Bicocca, Milan, Italy., de Wilde RF; Department of Surgery, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands., Del Chiaro M; Department of Surgery, University of Colorado School of Medicine. Aurora, CO., Di Benedetto F; Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy., Di Sebastiano P; Surgical Oncology, Pierangeli Clinic, Department of Innovative Technology in Medicine & Dentistry, G. D'Annunzio University Chieti-Pescara, Chieti, Italy., Dokmak S; Department of HPB Surgery and Liver Transplantation, Beaujon Hospital, Clichy, France.; University Paris Cité, Paris, France., Hogg M; Department of Surgery, Division of HPB Surgery, NorthShore University HealthSystem, Evanston, IL., Egorov VI; Department for Surgical Oncology and HPB Surgery, Ilyinskaya Hospital, Moscow, Russia., Ercolani G; Department of Medical and Surgical Sciences-DIMEC, Alma Mater Studiorum Università di Bologna, Bologna, Italy., Ettorre GM; Department of General Surgery and Transplantation. San Camillo Forlanini Hospital-POIT, Rome, Italy., Falconi M; Division of Pancreatic Surgery, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy., Ferrari G; Division of Minimally-Invasive Surgical Oncology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy., Ferrero A; Department of General and Oncological Surgery, 'Umberto I' Mauriziano Hospital, Turin, Italy., Filauro M; Department of Surgery Galliera Hospital, Genova, Italy., Giardino A; Hepatopancreatobiliary Surgery, Pederzoli Hospital, Peschiera del Garda, Verona, Italy., Grazi GL; Department of Experimental and Clinical Medicine, Division of HepatoBiliaryPancreatic Surgery, AOU Careggi, University of Florence, Florence, Italy., Gruttadauria S; Department for the Treatment and Study of Abdominal Diseases and Abdominal Transplantation, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IRCCS-ISMETT), University of Pittsburgh Medical Center Italy (UPMC Italy), Palermo, Italy.; Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, Italy., Izbicki JR; Department of General Visceral and Thoracic Surgery, University Hospital Eppendorf University of Hamburg, Hamburg, Germany., Jovine E; Alma Mater Studiorum University of Bologna, IRCCS AOU of Bologna, Bologna, Italy., Katz M; The University of Texas MD Anderson Cancer Center, Houston, TX., Keck T; Department of Surgery, University Medical Center Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Khatkov I; Department of High Technology Surgery, Moscow Clinical Scientific Center, Moscow, Russia., Kiguchi G; Department of Surgery, Hirakata Kohsai Hospital, Osaka, Japan., Kooby D; Department of Surgery, Emory University School of Medicine, Atlanta, GA., Lang H; University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany., Lombardo C; Division of General and Transplant Surgery, University of Pisa, Pisa, Italy., Malleo G; General and Pancreatic Surgery Unit, Pancreas Institute, University of Verona, Verona, Italy., Massani M; Department of Surgery, Regional Hospital of Treviso, Treviso, Italy., Mazzaferro V; Department of Oncology and Hemato-Oncology, University of Milan HPB Surgery and Liver Transplantation Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy., Memeo R; Department of Hepato-Pancreatc-Biliary Surgery, 'F. Miulli' General Regional Hospital, Acquaviva delle Fonti, Bari, Italy. Department of Medicine and Surgery, LUM University, Casamassima, Bari, Italy., Miao Y; Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.; Pancreas Institute, Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.; Pancreas Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China., Mishima K; Research Institute Against Digestive Cancer (IRCAD), Strasbourg, France., Molino C; Department of General and Speciality Surgery, General and Pancreatic Surgery Team 1, AORN A. Cardarelli, Naples, Italy., Nagakawa Y; Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Tokyo, Japan., Nakamura M; Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Nardo B; Department of Surgery and Robotic, Division of General Surgery, Annunziata Hub Hospital, School of Medicine Surgery and TD, University of Calabria, Cosenza, Italy., Panaro F; Department of Surgery, Division of HBP Surgery & Transplantation, Montpellier University Hospital School of Medicine, Montpellier, France., Pasquali C; Pancreatic & Digestive Endocrine Surgery Research Group-Department of Surgery, Oncology and Gastroenterology, DiSCOG, University of Padua, Padua, Italy., Perrone V; Division of General and Transplant Surgery, University of Pisa, Pisa, Italy., Rangelova E; Section for Upper Abdominal Surgery at the Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.; Department of Surgery at the Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Liu R; Second Department of Hepatopancreatobiliary Surgery, Chinese People's Liberation Army (PLA) General Hospital, Beijing, People's Republic of China., Romagnoli R; Division of General Surgery 2U-Liver Transplant Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy., Romito R; Division of General Surgery II and HPB Unit, A.O.U. Maggiore della Carità di Novara, Novara, Italy., Rosso E; Service de Chirurgie Générale, Mini-Invasive et Robotique, Centre Hôspitalier de., Schulick R; Department of Surgery, University of Colorado School of Medicine. Aurora, CO., Siriwardena A; Regional Hepato-Pancreato-Biliary Unit, Manchester Royal Infirmary, Manchester, UK., Spampinato MG; Department of General and Minimally Invasive Surgery, 'Vito Fazzi' Hospital, Lecce, Italy., Strobel O; Department of General Surgery, Division of Visceral Surgery, Medical University of Vienna, Vienna, Austria., Testini M; Department of Precision and Regenerative Medicine and Ionian Area (DiMePre-J), University of Bari, Bari, Italy., Troisi RI; Division of HBP, Minimally Invasive and Robotic Surgery, Transplantation Service Federico II University Hospital, Naples, Italy., Uzunoglo FG; Department of General Visceral and Thoracic Surgery, University Hospital Eppendorf University of Hamburg, Hamburg, Germany., Valente R; Department of Surgery, ASL3 Genovese, Genoa, Italy., Veneroni L; Chirurgia Generale e di Urgenza, Infermi Hospital Rimini, AUSL Romagna, Italy., Zerbi A; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.; Associazione Oncologica Pisana P. Trivella, Pisa, Italy., Vicente E; General Surgery Service,Sanchinarro University Hospital, HM Hospitals Faculty of Health Sciences Camilo José Cela University Madrid, Spain., Vistoli F; Department of Biotechnological and Applied Clinical Sciences, Division of General Surgery and Transplantation, University of L'Aquila, L'Aquila, Italy., Vivarelli M; Division of Hepatobiliary, Pancreatic and Transplantation Surgery, Polytechnic University of Marche, Ospedali Riuniti delle Marche, Ancona, Italy., Wakabayashi G; Center for Advanced Treatment of Hepatobiliary and Pancreatic Diseases, Ageo Central General Hospital, Saitama, Japan., Zanus G; Second Division of Surgery-Treviso-Department of Surgery, Oncology and Gastroenterology, DiSCOG, University of Padua, Padua, Italy., Zureikat A; Division of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA., Zyromski NJ; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN., Coppola R; Research Unit of General Surgery, Department of Medicine and Surgery, University Campus Bio-Medico di Roma, Rome, Italy.; Operative Research Unit of General Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy., D'Andrea V; Department of Surgery, Sapienza University of Rome, Rome, Italy., Davide J; Department of Surgery, HEBIPA-Hepatobiliary and Pancreatic Unit, Hospital de Santo António, Centro Hospitalar Universitário do Porto, Porto, Portugal., Dervenis C; Department HPB Surgery, Metropolitan Hospital, Athens, Greece., Frigerio I; Hepatopancreatobiliary Surgery, Pederzoli Hospital, Peschiera del Garda, Verona, Italy., Konlon KC; School of Medicine, Trinity College Dublin, Dublin, Ireland., Michelassi F; Department of Surgery, Weill Cornell Medicine, New York-Presbyterian Hospital at Weill Cornell, New York, NY., Montorsi M; Department of Biomedical Sciences, Humanitas University, Milan, Italy.; Department of General Surgery, Division of General and Digestive Surgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Nealon W; Department of Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY.; Zucker School of Medicine at Hofstra, New Hyde Park, NY., Portolani N; Department of Clinical and Experimental Sciences, Surgical Clinic, University of Brescia, Brescia, Italy., Sousa Silva D; Department of Surgery, HEBIPA-Hepatobiliary and Pancreatic Unit, Hospital de Santo António, Centro Hospitalar Universitário do Porto, Porto, Portugal., Bozzi G; Associazione per Donare la Vita Onlus, Pisa, Italy., Ferrari V; Associazione Nastro Viola, Brescia, Italy., Trivella MG; Associazione Oncologica Pisana P. Trivella, Pisa, Italy., Cameron J; Department of Surgery, John Hopkins University School of Medicine, Baltimore, MD., Clavien PA; Department of Surgery and Transplantation, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Asbun HJ; Division of Hepatobiliary and Pancreas Surgery, Miami Cancer Institute, Miami, FL.
Jazyk:	angličtina
Zdroj:	Annals of surgery [Ann Surg] 2024 Jul 01; Vol. 280 (1), pp. 56-65. Date of Electronic Publication: 2024 Feb 26.
DOI:	10.1097/SLA.0000000000006248
Abstrakt:	Objective: The REDISCOVER consensus conference aimed at developing and validating guidelines on the perioperative care of patients with borderline-resectable (BR-) and locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC). Background: Coupled with improvements in chemotherapy and radiation, the contemporary approach to pancreatic surgery supports the resection of BR-PDAC and, to a lesser extent, LA-PDAC. Guidelines outlining the selection and perioperative care for these patients are lacking. Methods: The Scottish Intercollegiate Guidelines Network (SIGN) methodology was used to develop the REDISCOVER guidelines and create recommendations. The Delphi approach was used to reach a consensus (agreement ≥80%) among experts. Recommendations were approved after a debate and vote among international experts in pancreatic surgery and pancreatic cancer management. A Validation Committee used the AGREE II-GRS tool to assess the methodological quality of the guidelines. Moreover, an independent multidisciplinary advisory group revised the statements to ensure adherence to nonsurgical guidelines. Results: Overall, 34 recommendations were created targeting centralization, training, staging, patient selection for surgery, possibility of surgery in uncommon scenarios, timing of surgery, avoidance of vascular reconstruction, details of vascular resection/reconstruction, arterial divestment, frozen section histology of perivascular tissue, extent of lymphadenectomy, anticoagulation prophylaxis, and role of minimally invasive surgery. The level of evidence was however low for 29 of 34 clinical questions. Participants agreed that the most conducive means to promptly advance our understanding in this field is to establish an international registry addressing this patient population ( https://rediscover.unipi.it/ ). Conclusions: The REDISCOVER guidelines provide clinical recommendations pertaining to pancreatectomy with vascular resection for patients with BR-PDAC and LA-PDAC, and serve as the basis of a new international registry for this patient population. Competing Interests: S.G.B.: support from Flinders Foundation grant: 49358025, NHMRC Ideas Grant: 2021009, Pankind 21.R7.INV.CB.UOSA.6.2. F.M.: Tsumura, Inc., Scientific Advisory Board. M.D.C. is a co-PI of a Boston Scientific–sponsored study and he has been awarded an industry grant by Haemonetics, Inc. M.H.: Intuitive Surgical—teaches courses and proctors. The remaining authors report no conflicts of interest. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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