Incidence and first trimester risk factors of stillbirth in Indonesia.

Autor:	Yusrika MU; 633485 Indonesian Prenatal Institute , Jakarta, Indonesia., Al Fattah AN; 633485 Indonesian Prenatal Institute , Jakarta, Indonesia.; Kosambi Maternal and Children Center, Jakarta, Indonesia., Kusuma RA; 633485 Indonesian Prenatal Institute , Jakarta, Indonesia.; Harapan Kita National Women and Children Hospital, Jakarta, Indonesia., Widjaja FF; 633485 Indonesian Prenatal Institute , Jakarta, Indonesia., Marizni S; 633485 Indonesian Prenatal Institute , Jakarta, Indonesia., Putri VP; 633485 Indonesian Prenatal Institute , Jakarta, Indonesia.; Kosambi Maternal and Children Center, Jakarta, Indonesia.
Jazyk:	angličtina
Zdroj:	Journal of perinatal medicine [J Perinat Med] 2024 Feb 27; Vol. 52 (4), pp. 392-398. Date of Electronic Publication: 2024 Feb 27 (Print Publication: 2024).
DOI:	10.1515/jpm-2023-0348
Abstrakt:	Objectives: To determine the incidence and the risk factors of stillbirth from maternal biophysical, ultrasound, and biochemical markers at 11-13 weeks of gestation in the Indonesian population. Methods: This was a retrospective cohort study of pregnant women for first-trimester preeclampsia screening at 11-13 weeks of gestation in some clinics and hospital in Jakarta. Maternal characteristics and history, mean arterial pressure (MAP) measurement, uterine artery pulsatility index (UtA-PI) ultrasound, maternal ophthalmic peak ratio (Oph-PR) Doppler, and placental growth factor (PlGF) serum were collected during the visit. Stillbirth was classified into placental dysfunction-related when it occurred with preeclampsia or birth weight <10th percentile and non-placental dysfunction-related. Bivariate and multivariate logistic regression analyses were employed to determine the risk factors associated with stillbirth. Results: Of 1,643 eligible participants, 13 (0.79 %) stillbirth cases were reported. More than half of the stillbirths (7) were placental dysfunction-related. After adjusted with maternal age, body mass index (BMI), and parity status, chronic hypertension (aOR (adjusted odds ratio)) 24.41, 95 % CI {confidence interval} 5.93-100.43), previous pregnancy with preeclampsia (aOR 15.79, 95 % CI 4.42-56.41), MAP >101.85 (aOR 26.67, 95 % CI 8.26-86.06), UtA-PI >1.90 (aOR 10.68, 95 % CI 2.34-48.58, and PlGF <28.77 pg/mL (aOR 18.60, 95 % CI 5.59-61.92) were associated with stillbirth. Conclusions: The incidence of stillbirth in the population is comparable to studies conducted in developed countries. Most routine variables assessed at the 11-13 weeks combined screening for preeclampsia are associated with the risk of stillbirth. (© 2024 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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