The Essential Role of Proteoglycans and Glycosaminoglycans in Odontogenesis.

Autor:	Chen J; Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.; School of Stomatology, Southern Medical University, Guangzhou, Guangdong, China., Sun T; Department of Periodontology, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong, China., Lin B; Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.; School of Stomatology, Southern Medical University, Guangzhou, Guangdong, China., Wu B; Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.; School of Stomatology, Southern Medical University, Guangzhou, Guangdong, China.; Southern Medical University-Shenzhen Stomatology Hospital (Pingshan), ShenZhen, China., Wu J; Center of Oral Implantology, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong, China.
Jazyk:	angličtina
Zdroj:	Journal of dental research [J Dent Res] 2024 Apr; Vol. 103 (4), pp. 345-358. Date of Electronic Publication: 2024 Feb 26.
DOI:	10.1177/00220345231224228
Abstrakt:	Tooth development and regeneration are regulated through a complex signaling network. Previous studies have focused on the exploration of intracellular signaling regulatory networks, but the regulatory roles of extracellular networks have only been revealed recently. Proteoglycans, which are essential components of the extracellular matrix (ECM) and pivotal signaling molecules, are extensively involved in the process of odontogenesis. Proteoglycans are composed of core proteins and covalently attached glycosaminoglycan chains (GAGs). The core proteins exhibit spatiotemporal expression patterns during odontogenesis and are pivotal for dental tissue formation and periodontium development. Knockout of core protein genes Biglycan , Decorin , Perlecan , and Fibromodulin has been shown to result in structural defects in enamel and dentin mineralization. They are also closely involved in the development and homeostasis of periodontium by regulating signaling transduction. As the functional component of proteoglycans, GAGs are negatively charged unbranched polysaccharides that consist of repeating disaccharides with various sulfation groups; they provide binding sites for cytokines and growth factors in regulating various cellular processes. In mice, GAG deficiency in dental epithelium leads to the reinitiation of tooth germ development and the formation of supernumerary incisors. Furthermore, GAGs are critical for the differentiation of dental stem cells. Inhibition of GAGs assembly hinders the differentiation of ameloblasts and odontoblasts. In summary, core proteins and GAGs are expressed distinctly and exert different functions at various stages of odontogenesis. Given their unique contributions in odontogenesis, this review summarizes the roles of proteoglycans and GAGs throughout the process of odontogenesis to provide a comprehensive understanding of tooth development. Competing Interests: Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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