Salvage skull base surgery after proton beam therapy for recurrent sinonasal malignancies: A retrospective study.

Autor: Okada S; Division of Head and Neck Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan., Mukaigawa T; Division of Head and Neck Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan., Goto S; Division of Head and Neck Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan., Hiiragi Y; Division of Head and Neck Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan., Sato F; Division of Pathology, Shizuoka Cancer Center Hospital, Shizuoka, Japan., Deguchi S; Division of Neurosurgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan., Ogawa H; Radiation and Proton Therapy Center, Shizuoka Cancer Center Hospital, Shizuoka, Japan., Onoe T; Radiation and Proton Therapy Center, Shizuoka Cancer Center Hospital, Shizuoka, Japan., Murayama S; Radiation and Proton Therapy Center, Shizuoka Cancer Center Hospital, Shizuoka, Japan., Yasunaga Y; Division of Plastic and Reconstructive Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan., Hayashi N; Division of Neurosurgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan.
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2024 Oct; Vol. 46 (10), pp. 2389-2397. Date of Electronic Publication: 2024 Feb 26.
DOI: 10.1002/hed.27709
Abstrakt: Background: This study aimed to examine treatment outcomes and postoperative complications associated with salvage skull base surgery following radical proton beam therapy (PBT).
Methods: Nine patients who underwent salvage skull base surgery following curative PBT as the initial treatment at our institution between September 2002 and May 2023 were retrospectively reviewed.
Results: The cohort comprised four males and five females with a mean age of 48.1 years. The average proton dose administered during initial therapy was 68.5 Gy (relative biological effectiveness). Among the salvage surgeries, eight were anterior skull base surgeries, and one was an anterior middle skull base surgery. No local recurrences or perioperative deaths were observed. Postoperative complications occurred in three patients (33.3%), all experiencing surgical site infections, with one also having cerebrospinal fluid leakage.
Conclusion: The study demonstrates that salvage skull base surgery after PBT effectively achieves local control and safety in patients with recurrent sinonasal malignancies.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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