Primary renal leukaemia in a young adult male as an extramedullary presentation of T cell acute lymphoblastic leukaemia.

Autor: Jain P; Haematology Oncology and Stem Cell Transplant Unit Apollo Hospitals Navi Mumbai India., Jain P; Helix Genetic and Pathology Laboratory Mumbai India., Ohgami RS; Hematopathology University of Utah Salt Lake City Utah USA., Pawar V; Hematopathology Apollo Hospitals Navi Mumbai India., Sehgal K; Hematopathology Sehgal Path Lab Private Limited Mumbai India., Chaudhari P; Hematopathology Apollo Hospitals Navi Mumbai India., Nikalji R; Nephrology Apollo Hospitals Navi Mumbai India., Singh T; Haematology Oncology and Stem Cell Transplant Unit Apollo Hospitals Navi Mumbai India., Khandelwal V; Haematology Oncology and Stem Cell Transplant Unit Apollo Hospitals Navi Mumbai India., Khare S; General Medicine Apollo Hospitals Navi Mumbai India., Lokhande V; General Medicine Apollo Hospitals Navi Mumbai India., Haridas A; Nephrology Apollo Hospitals Navi Mumbai India., Jessani L; Infectious Disease Apollo Hospitals Navi Mumbai India., Khandelwal K; Haematology Oncology and Stem Cell Transplant Unit Apollo Hospitals Navi Mumbai India.
Jazyk: angličtina
Zdroj: EJHaem [EJHaem] 2023 Nov 15; Vol. 5 (1), pp. 251-255. Date of Electronic Publication: 2023 Nov 15 (Print Publication: 2024).
DOI: 10.1002/jha2.820
Abstrakt: Primary renal involvement by T lymphoblasts is rare among adults with T acute lymphoblastic leukaemia. We report a 28-year-old man presenting with acute renal failure due to infiltration by T lymphoblasts and his response to paediatric-inspired modified BFM-90 protocol. The patient achieved an initial complete remission (CR) but developed central nervous system relapse. He achieved CR2 with cranial irradiation and intrathecal chemotherapy. He underwent a haploidentical transplant in CR2 and remains in remission post-transplant day 330. An early kidney biopsy helped confirm the diagnosis. Such presentations remain responsive to modified BFM-90. An early allotransplant in CR2 remains the standard of care.
Competing Interests: The authors declare no conflict of interest.
(© 2023 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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