Real-life effectiveness of carfilzomib in patients with relapsed multiple myeloma receiving treatment in the context of early access: The CARMYN study.

Autor: Laribi K; Hématologie clinique, CH Le Mans Le Mans France., Leleu X; Hématologie, CHU de Poitiers Poitiers France., Texier N; Epidémiologie, Kappa Santé Paris France., Germain R; Epidémiologie, Kappa Santé Paris France., Touzeau C; Hématologie Clinique, CHU de Nantes, CRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes Nantes France., Hammoud M; Hématologie, Hôpital Henri-Mondor AP-HP Créteil France., Payssot A; Hématologie Clinique, CHU de Dijon Dijon France., Schulmann S; Hématologie, CHU de Nancy Vandœuvre-Lès-Nancy France., Le Calloch R; Médecine Interne, Maladies Infectieuses et Maladies du Sang, CH de Cornouaille Quimper France., Trebouet A; Hématologie, CH Bretagne Sud Lorient France., Chaoui D; Hématologie, CH Victor Dupouy Argenteuil France., David S; Hématologie, Polyclinique Le Languedoc Narbonne France., Benbrahim O; Hématologie Clinique, Nouvel Hôpital d'Orléans Orléans France., Benramdane R; Hématologie, Hôpital René Dubos Pontoise France., Charvet-Rumpler A; Hématologie, CHRU Jean Minjoz Besançon Besançon France., Jadeau C; Plateforme de Recherche Clinique, CH Le Mans Le Mans France., Rouanet E; Plateforme de Recherche Clinique, CH Le Mans Le Mans France., Decaux O; Hématologie Clinique, CHU de Rennes Rennes France., Perrot A; Hématologie, CHU de Toulouse, IUC T-Oncopole Toulouse France.
Jazyk: angličtina
Zdroj: EJHaem [EJHaem] 2023 Dec 13; Vol. 5 (1), pp. 55-60. Date of Electronic Publication: 2023 Dec 13 (Print Publication: 2024).
DOI: 10.1002/jha2.828
Abstrakt: The real-life retrospective observational study CARMYN aimed at investigating the long-term efficacy and safety of carfilzomib in combination with dexamethasone and lenalidomide (KRd, 159 patients). These patients (62% in first and 38% in second relapse, median age 62 yo) were treated between 02/2014 and 02/2017. Most had been pre-exposed to bortezomib (98.2%) and to an IMID (75.4%). At the time of collection, 90% had permanently discontinued carfilzomib. Data collection was conducted from January to July 2021 in 27 participating sites, after a median of 39 months follow-up. For patients treated with KRd, an overall response rate of 78.4% translated in a median progression free survival (PFS) of 24.0 months (95% CI 18.8-27.6) and a median overall survival (OS) of 51.1 months (95% CI 41.3-not reached). Results were poorer but difficult to interpret in the small cohort of Kd recipients. The study is one of the longest real-life studies of carfilzomib treatment in patients in first or second relapse. CARMYN confirmed the real-life long-term efficacy of carfilzomib in combination with lenalidomide and dexamethasone with results similar to those of clinical trials. The KRd regimen is thus an option to consider for late relapses in the current context of MM management.
Competing Interests: KL received honoraria from AbbVie, AstraZeneca, Beigene, Iqone, Janssen, Novartis and Takeda. XL is a consultant and received honoraria from Amgen, Merck, BMS, GSK, Janssen, Oncopeptide, Takeda, Roche, Novartis, AbbVie, Sanofi, Gilead, Pfizer, Harpoon Therapeutic, Regeneron and Iteos. CT received adboards and honoraria from AMGEN. RLC received honoraria from Abbvie, Gilead, Takeda and Janssen.DC received honoraria from Roche. AP received honoraria from Abbvie, Amgen, BMS, Janssen, Pfizer, Sanofi & Takeda. The other authors declare no financial interests.
(© 2023 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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