Personalized Approach in the Management of Difficult-to-Treat and Treatment-Resistant Depression With Second-Generation Antipsychotics: A Delphi Statement.
| Autor: | Bhachech H; Department of Psychiatry, Santvan Clinic, Ahmedabad, IND., Nath K; Department of Psychiatry, Silchar Medical College and Hospital, Silchar, IND., Sidana R; Department of Psychiatry, Tekchand Sidana Memorial Psychiatric Hospital and Deaddiction Centre, Sriganganagar, IND., Shah N; Department of Psychiatry, Lokmanya Tilak Medical College, Sion, Mumbai, IND., Nagpal R; Department of Psychiatry, Manobal Clinic, New Delhi, IND., Sathianathan R; Department of Psychiatry, Madras Memory Clinic, Chennai, IND., Kakkad A; Medical Services, Torrent Pharmaceuticals Limited, Ahmedabad, IND., Korukonda K; Medical Services, Torrent Pharmaceuticals Limited, Ahmedabad, IND. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Jan 24; Vol. 16 (1), pp. e52878. Date of Electronic Publication: 2024 Jan 24 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.52878 |
| Abstrakt: | Background Major depressive disorder (MDD) has many facets including mixed or atypical depression that requires personalized care to improve treatment-related outcomes. Second-generation antipsychotics (SGAs) offer complementary mechanisms for clinical roles in difficult-to-treat depression and treatment-resistant depression cases. Aim/objective To further delineate a consensus on the clinical positioning of SGAs for MDD, mixed, or atypical depression, a Knowledge Attitude Perception (KAP)-mediated Delphi Statement was planned. Material/methods A literature review for the definition, diagnosis, and management of MDD, mixed, and atypical depression as treatment-resistant depression (TRD) or difficult-to-treat depression (DTD) was conducted by a steering committee of academic and clinical experts (n=6) while developing a validated KAP questionnaire. Scientific statements as clinical recommendations were evolved using the Delphi methodology before building a clinical expert consensus with an online survey (n=24). Results Twenty-four psychiatrists highlighted DTD to offer a multidimensional approach to assess treatment strategies involving selective serotonin reuptake inhibitors (SSRIs) or SGAs, while ensuring symptom, functional, and quality of life (QoL) domain improvement for improved outcomes and remission rates. MDD cases with anxiety, anhedonia, comorbidities, and risk traits require personalized care with early induction of SGAs for severe cases or symptom persisters with functional impairment. Early augmentation with SGAs including aripiprazole or cariprazine can provide a favorable risk-benefit profile for clinical cases of MDD with or without the antecedent of mixed depression or personality disorder. Conclusion The literature review and KAP responses emphasize the importance of early identification for personalized care strategies with SGAs for DTD. Large-scale real-world evidence needs to evolve with due recognition of different phenotypes as TRD or DTD with partial or functional impairment to understand the impact of appropriate treatment pathways with SGAs. Competing Interests: The authors have declared financial relationships, which are detailed in the next section. (Copyright © 2024, Bhachech et al.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|