Functional architecture of intracellular oscillations in hippocampal dendrites.

Autor:	Liao Z; Department of Neuroscience, Columbia University, New York, United States.; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States., Gonzalez KC; Department of Neuroscience, Columbia University, New York, United States.; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States., Li DM; Department of Neuroscience, Columbia University, New York, United States.; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States., Yang CM; Department of Neuroscience, Columbia University, New York, United States.; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States., Holder D; Department of Neuroscience, Columbia University, New York, United States.; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States., McClain NE; Department of Neuroscience, Columbia University, New York, United States.; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States., Zhang G; Department of Neurobiology, Stanford University, Stanford, United States., Evans SW; Department of Neurobiology, Stanford University, Stanford, United States., Chavarha M; Department of Bioengineering, Stanford University, Stanford, United States., Yi J; Department of Neuroscience, Columbia University, New York, United States.; Department of Neurology, Columbia University, New York, United States., Makinson CD; Department of Neuroscience, Columbia University, New York, United States.; Department of Neurology, Columbia University, New York, United States., Lin MZ; Department of Neurobiology, Stanford University, Stanford, United States.; Department of Bioengineering, Stanford University, Stanford, United States., Losonczy A; Department of Neuroscience, Columbia University, New York, United States.; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States.; Kavli Institute for Brain Science, Columbia University, New York, United States., Negrean A; Department of Neuroscience, Columbia University, New York, United States.; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 12. Date of Electronic Publication: 2024 Feb 12.
DOI:	10.1101/2024.02.12.579750
Abstrakt:	Fast electrical signaling in dendrites is central to neural computations that support adaptive behaviors. Conventional techniques lack temporal and spatial resolution and the ability to track underlying membrane potential dynamics present across the complex three-dimensional dendritic arbor in vivo . Here, we perform fast two-photon imaging of dendritic and somatic membrane potential dynamics in single pyramidal cells in the CA1 region of the mouse hippocampus during awake behavior. We study the dynamics of subthreshold membrane potential and suprathreshold dendritic events throughout the dendritic arbor in vivo by combining voltage imaging with simultaneous local field potential recording, post hoc morphological reconstruction, and a spatial navigation task. We systematically quantify the modulation of local event rates by locomotion in distinct dendritic regions and report an advancing gradient of dendritic theta phase along the basal-tuft axis, then describe a predominant hyperpolarization of the dendritic arbor during sharp-wave ripples. Finally, we find spatial tuning of dendritic representations dynamically reorganizes following place field formation. Our data reveal how the organization of electrical signaling in dendrites maps onto the anatomy of the dendritic tree across behavior, oscillatory network, and functional cell states. Competing Interests: Declaration of Interests The authors declare no competing interests.
Databáze:	MEDLINE
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