Making the case for resistance training in improving vascular function and skeletal muscle capillarization.

Autor:	McIntosh MC; School of Kinesiology, Auburn University, Auburn, AL, United States., Anglin DA; School of Kinesiology, Auburn University, Auburn, AL, United States., Robinson AT; School of Kinesiology, Auburn University, Auburn, AL, United States., Beck DT; School of Kinesiology, Auburn University, Auburn, AL, United States.; Edward Via College of Osteopathic Medicine-Auburn Campus, Auburn, AL, United States., Roberts MD; School of Kinesiology, Auburn University, Auburn, AL, United States.; Edward Via College of Osteopathic Medicine-Auburn Campus, Auburn, AL, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in physiology [Front Physiol] 2024 Feb 09; Vol. 15, pp. 1338507. Date of Electronic Publication: 2024 Feb 09 (Print Publication: 2024).
DOI:	10.3389/fphys.2024.1338507
Abstrakt:	Through decades of empirical data, it has become evident that resistance training (RT) can improve strength/power and skeletal muscle hypertrophy. Yet, until recently, vascular outcomes have historically been underemphasized in RT studies, which is underscored by several exercise-related reviews supporting the benefits of endurance training on vascular measures. Several lines of evidence suggest large artery diameter and blood flow velocity increase after a single bout of resistance exercise, and these events are mediated by vasoactive substances released from endothelial cells and myofibers (e.g., nitric oxide). Weeks to months of RT can also improve basal limb blood flow and arterial diameter while lowering blood pressure. Although several older investigations suggested RT reduces skeletal muscle capillary density, this is likely due to most of these studies being cross-sectional in nature. Critically, newer evidence from longitudinal studies contradicts these findings, and a growing body of mechanistic rodent and human data suggest skeletal muscle capillarity is related to mechanical overload-induced skeletal muscle hypertrophy. In this review, we will discuss methods used by our laboratories and others to assess large artery size/function and skeletal muscle capillary characteristics. Next, we will discuss data by our groups and others examining large artery and capillary responses to a single bout of resistance exercise and chronic RT paradigms. Finally, we will discuss RT-induced mechanisms associated with acute and chronic vascular outcomes. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 McIntosh, Anglin, Robinson, Beck and Roberts.)
Databáze:	MEDLINE
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