Interleukin-8 Promoter Polymorphism -251 A/T and Treatment Response in Neovascular Age-related Macular Degeneration.

Autor: Thomsen AK; Clinical Eye Research Division, Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Krogh Nielsen M; Clinical Eye Research Division, Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark., Liisborg C; Clinical Eye Research Division, Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark., Sørensen TL; Clinical Eye Research Division, Department of Ophthalmology, Zealand University Hospital, Roskilde, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Clinical ophthalmology (Auckland, N.Z.) [Clin Ophthalmol] 2024 Feb 21; Vol. 18, pp. 537-543. Date of Electronic Publication: 2024 Feb 21 (Print Publication: 2024).
DOI: 10.2147/OPTH.S448794
Abstrakt: Purpose: Interleukin-8 (IL-8) is a potent pro-angiogenic and pro-inflammatory chemokine, suggested to hold a role in neovascular age-related macular degeneration (nAMD). Our aim is to study the association of the single-nucleotide polymorphism -251 A/T (rs4073) in the IL-8 promoter region with the treatment response to intravitreal anti-vascular endothelial growth factor (VEGF) injections in nAMD.
Patients and Methods: This is a prospective study of treatment-naïve patients with nAMD. Treatment response after a loading dose of three intravitreal anti-VEGF injections was defined as functional response based on change in visual acuity, and morphological response based on change in central retinal thickness (CRT) and intraretinal fluid on optical coherence tomography. Morphological response was categorized in good, partial, and poor responders. Blood DNA was analyzed for -251 A/T genotype.
Results: The IL-8 promoter polymorphism -251 A/T was not significantly associated to functional treatment response ( P =0.09). No significant association was found between genotype and morphological treatment response ( P =0.799). Older age was significantly associated to good morphological responders compared to partial and poor responders ( P =0.014).
Conclusion: The IL-8 polymorphism -251 A/T is not associated to morphological nor functional treatment response to intravitreal anti-VEGF injections in patients with nAMD.
Competing Interests: The authors report no conflicts of interest in this work.
(© 2024 Thomsen et al.)
Databáze: MEDLINE
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