Genomic investigation on genes related to mercury metabolism in Amazonian indigenous populations.

Autor: Carvalho VHV; Núecleo de Pesquisas em Oncologia, Unidade de Alta Complexidade em Oncologia, Hospital Universitário João de Barros Barreto, 66073-005 Belém, Pará, Brazil. Electronic address: viktor_hug@hotmail.com., Rodrigues JCG; Núecleo de Pesquisas em Oncologia, Unidade de Alta Complexidade em Oncologia, Hospital Universitário João de Barros Barreto, 66073-005 Belém, Pará, Brazil., Vinagre LWMS; Núecleo de Pesquisas em Oncologia, Unidade de Alta Complexidade em Oncologia, Hospital Universitário João de Barros Barreto, 66073-005 Belém, Pará, Brazil., Pereira EEB; Núecleo de Pesquisas em Oncologia, Unidade de Alta Complexidade em Oncologia, Hospital Universitário João de Barros Barreto, 66073-005 Belém, Pará, Brazil., Monte N; Núecleo de Pesquisas em Oncologia, Unidade de Alta Complexidade em Oncologia, Hospital Universitário João de Barros Barreto, 66073-005 Belém, Pará, Brazil., Fernandes MR; Núecleo de Pesquisas em Oncologia, Unidade de Alta Complexidade em Oncologia, Hospital Universitário João de Barros Barreto, 66073-005 Belém, Pará, Brazil., Ribeiro-Dos-Santos AM; Laboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Universidade Federal do Pará, 66075-110, Belém, Pará, Brazil., Guerreiro JF; Laboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Universidade Federal do Pará, 66075-110, Belém, Pará, Brazil., Ribeiro-Dos-Santos Â; Laboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Universidade Federal do Pará, 66075-110, Belém, Pará, Brazil., Dos Santos SEB; Núecleo de Pesquisas em Oncologia, Unidade de Alta Complexidade em Oncologia, Hospital Universitário João de Barros Barreto, 66073-005 Belém, Pará, Brazil., Dos Santos NPC; Núecleo de Pesquisas em Oncologia, Unidade de Alta Complexidade em Oncologia, Hospital Universitário João de Barros Barreto, 66073-005 Belém, Pará, Brazil.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2024 May 01; Vol. 923, pp. 171232. Date of Electronic Publication: 2024 Feb 23.
DOI: 10.1016/j.scitotenv.2024.171232
Abstrakt: Studies have identified elevated levels of mercury in Amazonian Indigenous individuals, highlighting them as one of the most exposed to risks. In the unique context of the Brazilian Indigenous population, it is crucial to identify genetic variants with clinical significance to better understand vulnerability to mercury and its adverse effects. Currently, there is a lack of research on the broader genomic profile of Indigenous people, particularly those from the Amazon region, concerning mercury contamination. Therefore, the aim of this study was to assess the genomic profile related to the processes of mercury absorption, distribution, metabolism, and excretion in 64 Indigenous individuals from the Brazilian Amazon. We aimed to determine whether these individuals exhibit a higher susceptibility to mercury exposure. Our study identified three high-impact variants (GSTA1 rs1051775, GSTM1 rs1183423000, and rs1241704212), with the latter two showing a higher frequency in the study population compared to global populations. Additionally, we discovered seven new variants with modifier impact and a genomic profile different from the worldwide populations. These genetic variants may predispose the study population to more harmful mercury exposure compared to global populations. As the first study to analyze broader genomics of mercury metabolism pathways in Brazilian Amazonian Amerindians, we emphasize that our research aims to contribute to public policies by utilizing genomic investigation as a method to identify populations with a heightened susceptibility to mercury exposure.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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