Toxicological evaluation and concentration of airborne PM 0.1 in high air pollution period in Guangzhou, China.

Autor: Yang M; Department of Environmental and Biological Science, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, FI-70211 Kuopio, Finland; Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China., Wu QZ; Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China., Zhang YT; Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China., Leskinen A; Finnish Meteorological Institute, Yliopistonranta 1, P.O. Box 1627, FI-70211 Kuopio, Finland; Department of Technical Physics, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, FI-70211 Kuopio, Finland., Wang XF; Environment Research Institute, Shandong University, Qingdao 266237, China., Komppula M; Finnish Meteorological Institute, Yliopistonranta 1, P.O. Box 1627, FI-70211 Kuopio, Finland., Hakkarainen H; Department of Environmental and Biological Science, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, FI-70211 Kuopio, Finland., Roponen M; Department of Environmental and Biological Science, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, FI-70211 Kuopio, Finland., Jin NX; A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Neulaniementie 2, 70210 Kuopio, Finland., Tan WH; Department of Reproductive Medicine and Genetics Center, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China., Xu SL; Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China., Lin LZ; Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China., Liu RQ; Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China., Zeng XW; Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: zxw63@mail.sysu.edu.cn., Dong GH; Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address: donggh5@mail.sysu.edu.cn., Jalava PI; Department of Environmental and Biological Science, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, FI-70211 Kuopio, Finland.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2024 Apr 15; Vol. 921, pp. 171224. Date of Electronic Publication: 2024 Feb 24.
DOI: 10.1016/j.scitotenv.2024.171224
Abstrakt: The emissions and exposure limits for airborne PM 0.1 are lacking, with limited scientific data for toxicity. Therefore, we continuously monitored and calculated the number and mass concentrations of airborne PM 0.1 in December 2017, January 2018 and March 2018 during the high pollution period in Guangzhou. We collected PM 0.1 from the same period and analyzed their chemical components. A549, THP-1 and A549/THP-1 co-cultured cells were selected for exposure to PM 0.1 , and evaluated for toxicological responses. Our aims are to 1) measure and analyze the number and mass concentrations, and chemical components of PM 0.1 ; 2) evaluate and compare PM 0.1 toxicity to different airway cells models at different time points. Guangzhou had the highest mass concentration of PM 0.1 in December 2017, while the number concentration was the lowest. Chemical components in PM 0.1 vary significantly at different time periods, and the correlation between the chemical composition or source of PM 0.1 and the mass and number concentration of PM 0.1 was dissimilar. Exposure to PM 0.1 disrupted cell membranes, impaired mitochondrial function, promoted the expression of inflammatory mediators, and interfered with DNA replication in the cell cycle. The damage caused by exposure to PM 0.1 at different times exhibited variations across different types of cells. PM 0.1 in March 2018 stimulated co-cultured cells to secrete more inflammatory mediators, and CMA was significantly related to the expression of them. Our study indicates that it is essential to monitor both the mass and number concentrations of PM 0.1 throughout all seasons annually, as conventional toxicological experiments and the internal components of PM 0.1 may not effectively reveal the health damages caused by elevated number levels of PM 0.1 .
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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