Asymmetric dimethylarginine (ADMA) is associated with reduced myocardial mechano-energetic efficiency in hypertensive subjects.

Autor: Cefalo CMA; Department of Clinical and Molecular Medicine, University of Rome-Sapienza, Rome, Italy. Electronic address: chiaramariaassunta.cefalo@uniroma1.it., Riccio A; Department of Clinical and Molecular Medicine, University of Rome-Sapienza, Rome, Italy., Fiorentino TV; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy., Massimino M; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy., Mannino GC; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy., Succurro E; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy., Perticone M; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy., Sciacqua A; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy., Andreozzi F; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy., Perticone F; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy., Sesti G; Department of Clinical and Molecular Medicine, University of Rome-Sapienza, Rome, Italy.
Jazyk: angličtina
Zdroj: Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2024 May; Vol. 34 (5), pp. 1175-1178. Date of Electronic Publication: 2024 Jan 17.
DOI: 10.1016/j.numecd.2024.01.010
Abstrakt: Background and Aims: Our prior study showed that endothelial dysfunction contributed to reduced myocardial mechano-energetics efficiency (MEEi) independently of several confounders. Reduced activity of endothelial nitric oxide synthase may be due to increased levels of the endogenous inhibitor asymmetric dimethylarginine (ADMA). The impact of ADMA on myocardial MEEi has not been determined yet. This study aims to investigate the association between plasma ADMA levels and MEEi in drug-naïve hypertensive individuals.
Methods and Results: 63 hypertensive individuals participating in the CATAnzaro MEtabolic RIsk factors (CATAMERI) study were included. All participants underwent to an echocardiogram for myocardial MEEi measurement. ADMA plasma concentrations were measured by high-performance liquid chromatography. A multivariate linear regression analysis was conducted to investigate the independent association between ADMA levels and MEEi. In a univariate analysis, ADMA levels were significantly associated with myocardial MEEi (r = 0.438; P < 0.001). In a multivariate regression analysis, plasma ADMA levels were associated to decreased myocardial MEEi (β = 0.458, P < 0.001) independently of well-established cardiovascular risk factors including age, sex, BMI, waist circumference, smoking status, total cholesterol and HDL, triglycerides, glucose tolerance status, and HOMA-IR index of insulin resistance.
Conclusions: ADMA may contribute to reduced myocardial MEEi by reducing nitric oxide bioavailability.
Competing Interests: Declaration of competing interest The authors have no conflicts of interest in relation to this work.
(Copyright © 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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